Gender differences at presentation of idiopathic pulmonary fibrosis in Sweden

BMC Pulmonary Medicine

Table 3 Lung function parameters, 6MWT and K-BILD results divided by smoking status and gender

	Total		Never smoker		Ex-smoker
	Male	Female	Male	Female	Male	Female
Lung function
FVC% (N = 287)	N = 198	N = 89	N = 50	N = 37	N = 139	N = 47
	68.9 ± 14.4*	73.0 ± 17.7	69.7 ± 18.0	66.8 ± 16.8	68.7 ± 12.7**	75.8 ± 16.3
FEV1% (N = 307)	N = 215	N = 92	N = 54	N = 38	N = 152	N = 49
	76.1 ± 16.1	76.0 ± 17.7	76.8 ± 18.5	71.3 ± 18.9	76.4 ± 14.6	78.6 ± 16.1
TLC%, (N = 193)	N = 141	N = 52	N = 35	N = 21	N = 103	N = 31
	62.2 ± 11.8*	68.6 ± 11.3	61.8 ± 11.9	64.4 ± 10.8	62.0 ± 11.7***	71.3 ± 11.0
DLCO% (N = 221)	N = 158	N = 63	N = 39	N = 25	N = 113	N = 35
	45.2 ± 13.6	48.8 ± 14.4	49.7 ± 14.1	46.7 ± 14.2	43.8 ± 13.3*	49.3 ± 13.3
6WMT (N = 198)	N = 139	N = 59	N = 35	N = 22	N = 102	N = 35
6MWD, (M ± SD, m)	427 ± 128	411 ± 113	439 ± 136*	355 ± 140	426 ± 125	446 ± 79
B-SpO2% (M ± SD, %)	95.7 ± 2.30	95.9 ± 2.3	95.4 ± 2.0	95.8 ± 2.7	95.8 ± 2.4	95.9 ± 2.1
L-SpO2% (M ± SD, %)	85.9 ± 6.44	86.6 ± 7.4	85.8 ± 6.5	88.0 ± 8.5	85.8 ± 6.4	85.7 ± 6.6
K-BILD (N = 292)	N = 210	N = 82	N = 55	N = 33	N = 146	N = 44
Psychological	55.1 ± 16.6	54.9 ± 15.6	57.8 ± 16.1	53.0 ± 13.2	54.4 ± 17.0	55.6 ± 17.7
Breathlessness and activities	36.8 ± 18.7	40.0 ± 17.1	38.5 ± 21.9	34.5 ± 13.7	37.2 ± 17.1	41.3 ± 16.7
Chest symptoms	64.1 ± 21.7	66.0 ± 22.9	71.4 ± 21.4*	60.6 ± 20.4	62.5 ± 21.4	67.9 ± 24.2
Total	53.6 ± 10.9	54.3 ± 10.1	55.5 ± 11.1	51.8 ± 7.8	53.3 ± 11.0	55.1 ± 11.3

M mean, SD standard deviation, FVC% forced vital capacity, % of expected, FEV1% forced expiratory volume in first second, % of expected, TLC% total lung capacity, % of expected, DLCO% % diffusing capacity for carbon monoxide, 6MWD 6 min walking distance, B-SpO2% Saturation level for oxygen, at rest, L-SpO2% Saturation level for oxygen, lowest during/after test, K-BILD King’s Brief Interstitial Lung Disease questionnaire
*: p < 0.05, ** p < 0.01, *** p < 0.001 males vs. females