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Table 5 Multivariate analysis of clinical characteristics associated with (a) all-causes mortality, (b) respiratory-related mortality, and (c) cardiovascular-related mortality, in COPD patients

From: Major comorbidities lead to the risk of adverse cardiovascular events in chronic obstructive pulmonary disease patients using inhaled long-acting bronchodilators: a case-control study

 

OR

95% CI

P value

(a) All-causes mortality

Male

0.79

0.37

1.67

0.532

Age > 65

1.52

0.70

3.28

0.292

Smoking

0.87

0.50

1.53

0.634

BMI > 27

0.53

0.26

1.07

0.077

FEV1 < 50%

1.66

0.96

2.88

0.070

DM

0.70

0.36

1.37

0.297

Hyperlipidemia

0.58

0.22

1.58

0.289

CVD

1.73

1.00

2.97

0.048*

CKD

2.45

1.45

4.14

0.001*

LAMA

1.00

0.59

1.70

0.994

ICS/LABA

0.32

0.17

0.63

0.001*

History of exacerbations in the previous year

 1

1.43

0.78

2.63

0.243

  > 2

4.33

2.20

8.50

< 0.001**

Malignancy

 Lung cancer

27.24

12.16

61.04

< 0.001**

 Other cancer

19.39

7.85

47.87

< 0.001**

(b) Respiratory-related mortality

Male

0.83

0.34

1.98

0.667

Age > 65

1.19

0.52

2.70

0.681

Smoking

0.80

0.42

1.52

0.491

BMI > 27

0.48

0.20

1.15

0.100

FEV1 < 50%

1.82

0.97

3.41

0.060

DM

0.75

0.35

1.62

0.466

Hyperlipidemia

0.53

0.16

1.73

0.295

CVD

1.64

0.88

3.06

0.116

CKD

1.52

0.82

2.82

0.185

LAMA

1.11

0.61

2.03

0.739

ICS/LABA

0.40

0.19

0.83

0.014*

History of exacerbations in the previous year

 1

2.03

1.03

4.00

0.041*

  > 2

4.61

2.14

9.93

< 0.001**

Malignancy

 Lung cancer

35.79

15.65

81.82

< 0.001**

 Other cancer

11.72

4.27

32.17

< 0.001**

(c) Cardiovascular-related mortality

Male

0.79

0.19

3.33

0.745

Age > 65

3.06

0.38

24.76

0.294

Smoking

1.11

0.39

3.14

0.849

BMI > 27

0.85

0.26

2.79

0.793

FEV1 < 50%

1.40

0.49

4.00

0.527

DM

0.49

0.14

1.71

0.265

Hyperlipidemia

1.14

0.23

5.70

0.869

CVD

2.99

0.98

9.10

0.053

CKD

4.87

1.75

13.55

0.002*

LAMA

0.93

0.34

2.56

0.889

ICS/LABA

0.33

0.09

1.25

0.103

History of exacerbations in the previous year

 1

0.60

0.16

2.26

0.451

  > 2

2.01

0.57

7.12

0.277

Malignancy

 Lung cancer

1.43

0.17

12.34

0.742

 Other cancer

10.33

2.42

44.03

0.002*

  1. BMI body mass index, FEV1 forced expiratory volume in 1 second, DM diabetes mellitus, CVD cardiovascular disease, CKD chronic kidney disease, LAMA long-acting muscarinic antagonists, LABA long-acting beta2-agonists, ICS inhaled corticosteroids, CI confidence interval
  2. ** p < 0.001; *p < 0.05