| OR | 95% CI | P value | |
---|---|---|---|---|
(a) All-causes mortality | ||||
Male | 0.79 | 0.37 | 1.67 | 0.532 |
Age > 65 | 1.52 | 0.70 | 3.28 | 0.292 |
Smoking | 0.87 | 0.50 | 1.53 | 0.634 |
BMIÂ >Â 27 | 0.53 | 0.26 | 1.07 | 0.077 |
FEV1 < 50% | 1.66 | 0.96 | 2.88 | 0.070 |
DM | 0.70 | 0.36 | 1.37 | 0.297 |
Hyperlipidemia | 0.58 | 0.22 | 1.58 | 0.289 |
CVD | 1.73 | 1.00 | 2.97 | 0.048* |
CKD | 2.45 | 1.45 | 4.14 | 0.001* |
LAMA | 1.00 | 0.59 | 1.70 | 0.994 |
ICS/LABA | 0.32 | 0.17 | 0.63 | 0.001* |
History of exacerbations in the previous year | ||||
 1 | 1.43 | 0.78 | 2.63 | 0.243 |
  > 2 | 4.33 | 2.20 | 8.50 | < 0.001** |
Malignancy | ||||
 Lung cancer | 27.24 | 12.16 | 61.04 | < 0.001** |
 Other cancer | 19.39 | 7.85 | 47.87 | < 0.001** |
(b) Respiratory-related mortality | ||||
Male | 0.83 | 0.34 | 1.98 | 0.667 |
Age > 65 | 1.19 | 0.52 | 2.70 | 0.681 |
Smoking | 0.80 | 0.42 | 1.52 | 0.491 |
BMI > 27 | 0.48 | 0.20 | 1.15 | 0.100 |
FEV1 < 50% | 1.82 | 0.97 | 3.41 | 0.060 |
DM | 0.75 | 0.35 | 1.62 | 0.466 |
Hyperlipidemia | 0.53 | 0.16 | 1.73 | 0.295 |
CVD | 1.64 | 0.88 | 3.06 | 0.116 |
CKD | 1.52 | 0.82 | 2.82 | 0.185 |
LAMA | 1.11 | 0.61 | 2.03 | 0.739 |
ICS/LABA | 0.40 | 0.19 | 0.83 | 0.014* |
History of exacerbations in the previous year | ||||
 1 | 2.03 | 1.03 | 4.00 | 0.041* |
  > 2 | 4.61 | 2.14 | 9.93 | < 0.001** |
Malignancy | ||||
 Lung cancer | 35.79 | 15.65 | 81.82 | < 0.001** |
 Other cancer | 11.72 | 4.27 | 32.17 | < 0.001** |
(c) Cardiovascular-related mortality | ||||
Male | 0.79 | 0.19 | 3.33 | 0.745 |
Age > 65 | 3.06 | 0.38 | 24.76 | 0.294 |
Smoking | 1.11 | 0.39 | 3.14 | 0.849 |
BMI > 27 | 0.85 | 0.26 | 2.79 | 0.793 |
FEV1 < 50% | 1.40 | 0.49 | 4.00 | 0.527 |
DM | 0.49 | 0.14 | 1.71 | 0.265 |
Hyperlipidemia | 1.14 | 0.23 | 5.70 | 0.869 |
CVD | 2.99 | 0.98 | 9.10 | 0.053 |
CKD | 4.87 | 1.75 | 13.55 | 0.002* |
LAMA | 0.93 | 0.34 | 2.56 | 0.889 |
ICS/LABA | 0.33 | 0.09 | 1.25 | 0.103 |
History of exacerbations in the previous year | ||||
 1 | 0.60 | 0.16 | 2.26 | 0.451 |
  > 2 | 2.01 | 0.57 | 7.12 | 0.277 |
Malignancy | ||||
 Lung cancer | 1.43 | 0.17 | 12.34 | 0.742 |
 Other cancer | 10.33 | 2.42 | 44.03 | 0.002* |