Table 1 The mean, SD (standard deviation), P25 (25th percentile), P50 (median), & P75 (75th percentile) of LPS (1 μg/ml)-stimulated cytokine production in BAL-derived human alveolar macrophage supernatant concentrations measured at 24 h in the presence of surfactants. Control samples - LPS –stimulated AMs
Control | Curosurf® | Liposurf® | Synsurf® | |
|---|---|---|---|---|
IL-1β (pg/ml) | ||||
Mean | 176.45 | 168.87 | 118.01 | 97.6 |
SD | 305.32 | 292.62 | 210.07 | 166.01 |
P25 | 0.09 | 0.3 | 0.34 | 0.27 |
P50 | 0.25 | 0.39 | 1.29 | 0.6 |
P75 | 529 | 495.5 | 300.5 | 332 |
IL2 (pg/ml) | ||||
Mean | 7.61 | 5.16 | 4.38 | 10.91 |
SD | 1126 | 7.77 | 5.84 | 19.03 |
P25 | 0.017 | 0.14 | 0.22 | 0.14 |
P50 | 0.0722 | 0.38 | 0.022 | 0.31 |
P75 | 1951 | 7.25 | 8.86 | 27.45 |
IL6 (pg/ml) | ||||
Mean | 650.4 | 452.78 | 321.08 | 265.7 |
SD | 1126 | 815.29 | 634.03 | 412.02 |
P25 | 0.017 | 0.17 | 0.07 | 0.14 |
P50 | 0.0722 | 0.29 | 0.18 | 0.24 |
P75 | 1951 | 1134 | 341 | 759.5 |
IL8 (pg/ml) | ||||
Mean | 3588 | 3193.71 | 3139.73 | 3101.79 |
SD | 6020 | 5153.64 | 5081.01 | 4997.25 |
P25 | 55.35 | 89 | 84.5 | 95.75 |
P50 | 169 | 249.5 | 251 | 198.5 |
P75 | 10,540 | 10,532.5 | 10,316.5 | 10,273 |
TNF-α (pg/ml) | ||||
Mean | 462 | 120.73 | 110.01 | 56.87 |
SD | – | 195.09 | 181.01 | 99.96 |
P25 | – | 0.08 | 0.1 | 0.08 |
P50 | – | 0.13 | 30.98 | 0.13 |
P75 | – | 273.5 | 219.93 | 95.35 |
INF-γ (pg/ml) | ||||
Mean | 5.771 | 1.93 | 3.06 | 1.12 |
SD | 8.039 | 2.5 | 4.8 | 0.85 |
P25 | 0.0864 | 0.28 | 0.45 | 0.55 |
P50 | 5.771 | 0.49 | 0.82 | 0.6 |
P75 | 11.46 | 2.57 | 5.68 | 1.75 |
GM-CSF (pg/ml) | ||||
Mean | 114.1 | 84.5 | 61.89 | 62.33 |
SD | 197.3 | 157.67 | 129.1 | 107.94 |
P25 | 0.1176 | 0.28 | 0.21 | 0.06 |
P50 | 0.2565 | 0.35 | 0.42 | 0.22 |
P75 | 342 | 183 | 86.3 | 184 |
IL10 (pg/ml) | ||||
Mean | 0.186 | 18.05 | 15.58 | 4.88 |
SD | – | 29.7 | 29.76 | 8.36 |
P25 | – | 0.1244 | 0.11435 | 0.157 |
P50 | – | 0.176 | 1.012 | 0.1635 |
P75 | – | 21.25 | 31.0475 | 4.55 |
IL12 (pg/ml) | ||||
Mean | 2.93 | 20.1 | 15.39 | 16.14 |
SD | 3.966 | 39.377 | 18.07 | 22.08 |
P25 | 0.1259 | 0.24 | 0.21 | 0.34 |
P50 | 2.93 | 0.56 | 12.74 | 0.35 |
P75 | 5.735 | 39.95 | 30.58 | 33.7 |