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Fig. 3 | BMC Pulmonary Medicine

Fig. 3

From: Dose-response relationship of ICS/fast-onset LABA as reliever therapy in asthma

Fig. 3

Schematic dose-response curves of severe exacerbation risk for the budesonide/formoterol reliever therapy (orange/green) and the maintenance budesonide/formoterol therapy (blue) regimens based on data presented in this review. The X-axis represents the daily dose of budesonide/formoterol on a logarithmic scale. The Y-axis represents the response in terms of reduction in risk of a severe exacerbation. There were a number of assumptions made in deriving this figure: i) the budesonide/formoterol reliever therapy curve is derived from the study of budesonide/formoterol reliever monotherapy [12] (orange) and the study of budesonide/formoterol reliever therapy used in addition to maintenance budesonide/formoterol therapy [13] (green). ii) the therapeutic effect of budesonide/formoterol reliever monotherapy is set as 50% of the maximum drug response and the therapeutic effect of budesonide/formoterol maintenance and reliever therapy is set as 100% of the maximum drug response. iii) the shape of the log exponential dose-response curve is assumed

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