Fig. 6

Analyses of lung inflammation and fibrosis in mice. a) Representative pathological photographs of lung tissue of WT or Tg mice 21 days after the administration of saline or BLM. Lung inflammation and fibrosis in Tg-BLM were greater than those in WT-BLM. b) Consolidation and traction bronchiectasis were observed in both WT-BLM and Tg-BLM at day 21 using micro-CT. These findings were more extensively observed in Tg-BLM than in WT-BLM. c) Ashcroft score 21 days after the administration of saline or BLM. The Ashcroft score in Tg-BLM was significantly higher than that in WT-BLM. d) The protein level of fibronectin at 21 days was significantly higher in Tg-BLM than that in WT-BLM. e) The mRNA level of fibronectin at 21 days was significantly higher in Tg-BLM than that in WT-BLM