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Table 1 Characteristics of healthy volunteers and patients with S-IPF and AE-IPF

From: The overexpression of peroxiredoxin-4 affects the progression of idiopathic pulmonary fibrosis

 

HV (n = 15)

S-IPF (n = 51)

AE-IPF (n = 38)

Three groups, p-value

HV/S-IPF, p-value

HV/AE-IPF, p-value

S-IPF/AE-IPF, p-value

Age, years

36 (34–40)

72 (68–75)

72 (64–75)

<  0.001

<  0.001

<  0.001

0.983

Sex, male

13 (87)

39 (76)

35 (92)

0.217

0.396

0.542

0.051

BMI

22.9 (20.9–24.8)

22.9 (20.7–24.7)

22.9 (21.1–25.8)

0.785

0.786

0.875

0.480

Smoking history, never/former/current

15/0/0

12/30/9

2/31/5

<  0.001

<  0.001

<  0.001

0.254

PaO2/FiO2 ratio, mmHg

–

395 (324–429)

220 (128–296)

–

–

–

<  0.001

A-a DO2, mmHg

–

14 (9–31)

135 (58–251)

–

–

–

<  0.001

FVCa, L

–

2.00 (1.43–2.66)

1.85 (1.73–2.31)

–

–

–

0.674

FVCa, % predicted

–

67 (55–79)

54 (47–68)

–

–

–

0.039

DLCOb, % predicted

–

66 (43–83)

37 (29–49)

–

–

–

0.005

Overall survivalc, days

–

1059

57

–

–

–

<  0.001

  1. Data are presented as median (interquartile range) or n (%)
  2. aThe numbers of patients with FVC measured were as follows: S-IPF (n = 51), AE-IPF (n = 15)
  3. bThe numbers of patients with DLCO measured were as follows: S-IPF (n = 35), AE-IPF (n = 10)
  4. cThe date of baseline of overall survival is the day of diagnosis of S-IPF and AE-IPF
  5. Abbreviations: AE-IPF Acute exacerbation of idiopathic pulmonary fibrosis, A-a DO2 Alveolar-arterial difference of oxygen, BMI Body mass index, DLCO Diffusing capacity of the lungs for carbon monoxide, FVC Forced vital capacity, HV Healthy volunteer, PaO2/FiO2 Arterial partial pressure of oxygen/fraction of inspired oxygen, S-IPF Stable idiopathic pulmonary fibrosis
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BMC Pulmonary Medicine

ISSN: 1471-2466

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