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Table 1 Characteristics of healthy volunteers and patients with S-IPF and AE-IPF

From: The overexpression of peroxiredoxin-4 affects the progression of idiopathic pulmonary fibrosis

 HV (n = 15)S-IPF (n = 51)AE-IPF (n = 38)Three groups, p-valueHV/S-IPF, p-valueHV/AE-IPF, p-valueS-IPF/AE-IPF, p-value
Age, years36 (34–40)72 (68–75)72 (64–75)<  0.001<  0.001<  0.0010.983
Sex, male13 (87)39 (76)35 (92)0.2170.3960.5420.051
BMI22.9 (20.9–24.8)22.9 (20.7–24.7)22.9 (21.1–25.8)0.7850.7860.8750.480
Smoking history, never/former/current15/0/012/30/92/31/5<  0.001<  0.001<  0.0010.254
PaO2/FiO2 ratio, mmHg395 (324–429)220 (128–296)<  0.001
A-a DO2, mmHg14 (9–31)135 (58–251)<  0.001
FVCa, L2.00 (1.43–2.66)1.85 (1.73–2.31)0.674
FVCa, % predicted67 (55–79)54 (47–68)0.039
DLCOb, % predicted66 (43–83)37 (29–49)0.005
Overall survivalc, days105957<  0.001
  1. Data are presented as median (interquartile range) or n (%)
  2. aThe numbers of patients with FVC measured were as follows: S-IPF (n = 51), AE-IPF (n = 15)
  3. bThe numbers of patients with DLCO measured were as follows: S-IPF (n = 35), AE-IPF (n = 10)
  4. cThe date of baseline of overall survival is the day of diagnosis of S-IPF and AE-IPF
  5. Abbreviations: AE-IPF Acute exacerbation of idiopathic pulmonary fibrosis, A-a DO2 Alveolar-arterial difference of oxygen, BMI Body mass index, DLCO Diffusing capacity of the lungs for carbon monoxide, FVC Forced vital capacity, HV Healthy volunteer, PaO2/FiO2 Arterial partial pressure of oxygen/fraction of inspired oxygen, S-IPF Stable idiopathic pulmonary fibrosis