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Fig. 2 | BMC Pulmonary Medicine

Fig. 2

From: Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis

Fig. 2

Circ-ABCB10 sponges miR-556-3p in lung cancer. a The subcellular localization of circ-ABCB10 was detected by subcellular fractionation and FISH assays. b MiRNAs that could bind with circ-ABCB10 were predicted through starBase. c RT-qPCR analysis of miR-556-3p expression in transfected cells. d RT-qPCR analysis of miR-556-3p expression in lung cancer cells and HBE cells. e A binding site between circ-ABCB10 and miR-556-3p was predicted via starBase. f The efficiency of miR-556-3p overexpression was analyzed via RT-qPCR. g-h The interaction between circ-ABCB10 and miR-556-3p was testified by luciferase reporter and RIP assays. i The efficacy of miR-556-3p inhibition was analyzed via RT-qPCR. j-m Cell proliferation, apoptosis and migration in different groups were separately evaluated by CCK-8, colony formation, TENEL and transwell assays. **P < 0.01

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