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Fig. 3 | BMC Pulmonary Medicine

Fig. 3

From: Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis

Fig. 3

Circ-ABCB10 regulates AK4 expression by sponging miR-556-3p in lung cancer. a Venn pattern showed the overlap of the prediction results of four databases. b-c AK4 expression in transfected cells were examined through RT-qPCR together with western blot. d The expression of AK4 in lung cells and HBE cells was observed via RT-qPCR and western blot. e Measurement of RNA enrichments through RIP and RT-qPCR. f A binding site between miR-556-3p and AK4 predicted by starBase was shown. g The efficiency of AK4 overexpression was analyzed via RT-qPCR. h The interaction between RNAs was confirmed by luciferase reporter assay. i The efficiency of AK4 knockdown was analyzed via RT-qPCR. j-m Cell proliferation, apoptosis and migration in different groups were separately evaluated by CCK-8, colony formation, TENEL and transwell assays. *P < 0.05, **P < 0.01

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