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Table 1 Comparison between healthy controls and patients with COPD as a whole

From: Specific motor cortex hypoexcitability and hypoactivation in COPD patients with peripheral muscle weakness

 Controls n = 20COPD n = 40p-value (t-test)
Anthropometric parameters
 Gender, M/F10/1021/19
 Age, yrs61.3 (2.17)61.7 (1.73)0.97
 Weight, kg72 (2.59)73 (3.96)0.89
 BMI, kg.m−225.4 (0.76)26.4 (1.26)0.46
Pulmonary parameters
 FEV1, L3.12 (0.2)1.3 (0.11)< 0.001
 FEV1, % pred113.9 (3.2)49.6 (3.66)< 0.001
 FEV1/FVC0.74 (0.46)0.5 (0.28)< 0.001
Maximal voluntary and electrically evoked quadriceps torque
 QMVC, Nm150.3 (15.7)99 (10.4)< 0.05
 QPt, Nm43.1 (3.71)33.5 (3.32)< 0.05
Voluntary activation parameters
 VAperipheral93 (1)93.1 (1.32)0.94
 VAcortical, %89.8 (1.02)85.7 (3.11)0.26
Peripheral and spinal parameters
 Mmax amplitude, mV3.94 (0.38)3.32 (0.5)0.36
 Mmax lat, ms5.7 (0.27)6.15 (0.25)0.38
 Hmax/Mmax0.188 (0.027)0.26 (0.029)0.34
 Hmax lat, ms16.63 (0.54)18.98 (0.59)< 0.01
Corticospinal parameters
 MEP/Mmax0.374 (0.021)0.34 (0.045)0.68
 CMCT, ms20.3 (0.56)20.2 (0.54)0.59
 CSP, ms75.6 (7.2)103 (4.43)< 0.001
  1. BMI body mass index, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, QMVC quadriceps maximal voluntary torque, QPt quadriceps peak twitch, Cortical VA primary motor cortex activation, Mmax amplitude amplitude of the maximal M-wave, Mmax lat latency of the maximal M-wave, Hmax/Mmax amplitude of the maximal H-wave normalized with respect to the maximal M-wave, Hmax - Mmax lat latency of the maximal H-wave minus the latency of the maximal M-wave, MEP/Mmax amplitude of the maximal motor evoked potential normalized with respect to the maximal M-wave amplitude, CMCT central motor conduction time, CSP cortical silent period. Data are expressed as mean and SE