Skip to main content
Fig. 4 | BMC Pulmonary Medicine

Fig. 4

From: Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide

Fig. 4

Histological evaluation of H&E-stained sections of tissues (lung, heart, kidney, liver, spleen, and intestine) harvested from SPA4 peptide-treated, vehicle-treated, and untreated CD-1 mice. Major organs were harvested from mice at the time of necropsy and fixed in 10% buffered-formalin overnight, dehydrated, embedded in paraffin, sectioned, and stained with H&E. Tissue sections were evaluated for any evidence of tissue damage and inflammation by board-certified veterinary pathologists. Representative photomicrographs are shown from respective tissue section for each study group (11–15 mice per group, seven groups total) revealing normal histology. Atypical findings in isolated specimens (shown as*) from one mouse in selected study groups are shown, which are not related to the dose of SPA4 peptide or study design

Back to article page