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Table 2 Blood gas and electrolyte measurements in fresh blood harvested from CD-1 mice intratracheally administered with different doses of SPA4 peptide. Results are mean (SEM) of values obtained from 3 to 5 mice representative of 11–15 mice per group included in four separate experiments. One-way ANOVA followed by Tukey’s post hoc test was used for statistical analysis

From: Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide

Blood gas and electrolytesTreatment Group
UntreatedVehicle0.625 μg/g bwa1.25 μg/g bw2.5 μg/g bw5 μg/g bw10 μg/g bw
pCO2 mmHg54.00 (5.20)64.00 (6.25)58.50 (4.33)42.67(11.39)52.75 (6.51)60.33 (5.24)65.67 (4.70)
HCO3 mmol/L22.88 (1.03)22.47 (0.72)23.18 (0.57)23.30 (1.05)22.98 (1.15)21.73 (0.38)23.57 (0.58)
tCO2 mmol/L24.54 (1.18)24.43 (0.90)25.00 (0.50)24.60 (0.70)24.60 (1.28)23.30 (0.21)25.60 (0.69)
pO2 mmHg29.20 (5.74)34.00 (10.21)27.50 (3.52)35.67 (2.91)37.50 (8.66)38.67 (6.77)24.67 (2.03)
tHB g/dL15.20 (0.61)14.03 (0.50)15.00 (0.29)12.03 (2.68)14.18 (1.31)11.43 (3.23)15.27 (0.41)
Anion gap mmol/L15.02 (0.38)16.50 (0.85)16.63 (1.15)15.47 (2.49)16.03 (1.09)18.30 (0.76)17.03 (0.42)
Base excess (mmol/L)4.50 (0.21)7.03 (0.35)5.23 (1.42)6.10b (0.79)4.13 (1.17)7.27 (1.54)6.10 (0.60)
Blood pH7.27 (0.03)7.19 (0.03)7.24 (0.04)7.42 (0.16)7.29 (0.04)7.20 (0.04)7.20 (0.02)
Na+ mmol/L145.4 (0.51)147.3 (0.33)148 (1.29)147.7 (1.45)146.3 (1.44)148.0 (0.58)148.0 (1.00)
K+ mmol/L4.84 (0.21)4.83 (0.69)3.65 (0.17)4.43 (0.59)6.25 (1.33)3.97 (0.18)4.30 (0.12)
Cl mmol/L112.0 (0.84)113.3 (1.33)111.8 (1.18)113.3 (0.88)112.8 (0.25)111.7 (0.33)111.7 (1.33)
  1. abw body weight, ball values for base excess were negative except for one mouse