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Table 2 Blood gas and electrolyte measurements in fresh blood harvested from CD-1 mice intratracheally administered with different doses of SPA4 peptide. Results are mean (SEM) of values obtained from 3 to 5 mice representative of 11–15 mice per group included in four separate experiments. One-way ANOVA followed by Tukey’s post hoc test was used for statistical analysis

From: Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide

Blood gas and electrolytes

Treatment Group

Untreated

Vehicle

0.625 μg/g bwa

1.25 μg/g bw

2.5 μg/g bw

5 μg/g bw

10 μg/g bw

pCO2 mmHg

54.00 (5.20)

64.00 (6.25)

58.50 (4.33)

42.67(11.39)

52.75 (6.51)

60.33 (5.24)

65.67 (4.70)

HCO3 mmol/L

22.88 (1.03)

22.47 (0.72)

23.18 (0.57)

23.30 (1.05)

22.98 (1.15)

21.73 (0.38)

23.57 (0.58)

tCO2 mmol/L

24.54 (1.18)

24.43 (0.90)

25.00 (0.50)

24.60 (0.70)

24.60 (1.28)

23.30 (0.21)

25.60 (0.69)

pO2 mmHg

29.20 (5.74)

34.00 (10.21)

27.50 (3.52)

35.67 (2.91)

37.50 (8.66)

38.67 (6.77)

24.67 (2.03)

tHB g/dL

15.20 (0.61)

14.03 (0.50)

15.00 (0.29)

12.03 (2.68)

14.18 (1.31)

11.43 (3.23)

15.27 (0.41)

Anion gap mmol/L

15.02 (0.38)

16.50 (0.85)

16.63 (1.15)

15.47 (2.49)

16.03 (1.09)

18.30 (0.76)

17.03 (0.42)

Base excess (mmol/L)

4.50 (0.21)

7.03 (0.35)

5.23 (1.42)

6.10b (0.79)

4.13 (1.17)

7.27 (1.54)

6.10 (0.60)

Blood pH

7.27 (0.03)

7.19 (0.03)

7.24 (0.04)

7.42 (0.16)

7.29 (0.04)

7.20 (0.04)

7.20 (0.02)

Na+ mmol/L

145.4 (0.51)

147.3 (0.33)

148 (1.29)

147.7 (1.45)

146.3 (1.44)

148.0 (0.58)

148.0 (1.00)

K+ mmol/L

4.84 (0.21)

4.83 (0.69)

3.65 (0.17)

4.43 (0.59)

6.25 (1.33)

3.97 (0.18)

4.30 (0.12)

Cl− mmol/L

112.0 (0.84)

113.3 (1.33)

111.8 (1.18)

113.3 (0.88)

112.8 (0.25)

111.7 (0.33)

111.7 (1.33)

  1. abw body weight, ball values for base excess were negative except for one mouse