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Table 1 Baseline characteristics of the 17 patients at Burkholderia primary colonisation

From: Management of initial colonisations with Burkholderia species in France, with retrospective analysis in five cystic fibrosis Centres: a pilot study

Patient characteristics (N = 17)

Number (percentage) or median value [min-max]

Male gender

13 (76.5%)

Age (years)

19 [6–34]

CFTR genotype: F508del/F508del

3 (17.6%)

 F508del/other or unknown

12 (70.6%)

 Other or unknown

2 (11.8%)

BMI (Z-score)

−0.76 [−2.81–0.39]

Insulin-dependent diabetes

3 (17.6%)

Exocrine pancreatic insufficiency

16 (94.1%)

Nutritional support (gastrostomy/enteral tube)

1 (5.9%)

Liver cirrhosis

1 (5.9%)

ABPA

3 (17.6%)

Respiratory function tests

 Median FEV1 (% predicted)

83.0 [26–113]

 Median FVC (% predicted)

92.0 [36–109]

Burkholderiaspecies

BCC

14 (82.4%)

B. multivorans

6 (35.3%)

B. cenocepaciaa

4 (23.5%)

B. contaminans

1 (5.9%)

B. vietnamiensis

1 (5.9%)

B. ambifaria

1 (5.9%)

 Unidentified BCCb

1 (5.9%)

B. gladioli

3 (17.6%)

Co-pathogens

 Methi-S Staphylococcus aureus

7 (41.2%)

 Methi-R Staphylococcus aureus

5 (29.4%)

Pseudomonas aeruginosa

6 (35.3%)

 Fungi

4 (23.5%)

Stenotrophomonas maltophilia

3 (17.6%)

 Non-tuberculous Mycobacteria

2 (11.8%)

Achromobacter spp.

0 (0%)

  1. CFTR Cystic Fibrosis Transmembrane conductance Regulator, BMI Body Mass Index, ABPA Allergic Broncho-Pulmonary Aspergillosis, FEV1 Forced Expiratory Volume in one second, FVC Forced Vital Capacity, BCC Burkholderia cepacia complex, Methi-S Methicillin-Susceptible,Methi-R Methicillin-Resistant
  2. a including 3 cenocepacia IIIA and 1 cenocepacia IIIB subtypes
  3. bon the basis of RecA sequencing results analysed using the Burkholderia cepacia complex MLST Databases website (https://pubmlst.org/bcc/), this isolate was confirmed as BCC, but could not be assigned to any of the BCC species described so far