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Table 1 Baseline characteristics of the 17 patients at Burkholderia primary colonisation

From: Management of initial colonisations with Burkholderia species in France, with retrospective analysis in five cystic fibrosis Centres: a pilot study

Patient characteristics (N = 17)Number (percentage) or median value [min-max]
Male gender13 (76.5%)
Age (years)19 [6–34]
CFTR genotype: F508del/F508del3 (17.6%)
 F508del/other or unknown12 (70.6%)
 Other or unknown2 (11.8%)
BMI (Z-score)−0.76 [−2.81–0.39]
Insulin-dependent diabetes3 (17.6%)
Exocrine pancreatic insufficiency16 (94.1%)
Nutritional support (gastrostomy/enteral tube)1 (5.9%)
Liver cirrhosis1 (5.9%)
ABPA3 (17.6%)
Respiratory function tests
 Median FEV1 (% predicted)83.0 [26–113]
 Median FVC (% predicted)92.0 [36–109]
Burkholderiaspecies
BCC14 (82.4%)
B. multivorans6 (35.3%)
B. cenocepaciaa4 (23.5%)
B. contaminans1 (5.9%)
B. vietnamiensis1 (5.9%)
B. ambifaria1 (5.9%)
 Unidentified BCCb1 (5.9%)
B. gladioli3 (17.6%)
Co-pathogens
 Methi-S Staphylococcus aureus7 (41.2%)
 Methi-R Staphylococcus aureus5 (29.4%)
Pseudomonas aeruginosa6 (35.3%)
 Fungi4 (23.5%)
Stenotrophomonas maltophilia3 (17.6%)
 Non-tuberculous Mycobacteria2 (11.8%)
Achromobacter spp.0 (0%)
  1. CFTR Cystic Fibrosis Transmembrane conductance Regulator, BMI Body Mass Index, ABPA Allergic Broncho-Pulmonary Aspergillosis, FEV1 Forced Expiratory Volume in one second, FVC Forced Vital Capacity, BCC Burkholderia cepacia complex, Methi-S Methicillin-Susceptible,Methi-R Methicillin-Resistant
  2. a including 3 cenocepacia IIIA and 1 cenocepacia IIIB subtypes
  3. bon the basis of RecA sequencing results analysed using the Burkholderia cepacia complex MLST Databases website (https://pubmlst.org/bcc/), this isolate was confirmed as BCC, but could not be assigned to any of the BCC species described so far