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Table 2 Organ involvement and histological evidence indicating subjects with evidence of noncaseating granulomas

From: Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts

Characteristics Organ Involvement per WASOG Tool Histological Evidence
n/187 % 95% CI n/total %
Lung 184 98.4 95.4–99.7 158/184 85.9
Skin 27 14.4 9.7–20.3 22/27 81.5
Liver 33 17.6 12.5–23.9 12/33 36.4
Eye 39 20.9 15.3–27.4 5/39 12.8
Spleen 39 20.9 15.3–27.4 2/39 5.1
Salivary Gland 4 2.1 0.6–5.4 1/4 25.0
ENT 4 2.1 0.6–5.4 3/4 75.0
Calcium-VitD 10 5.3 2.6–9.6 0/10a 0.0
Bone-Joint 18b 9.6 5.8–14.8 3/18 16.7
Bone Marrow 6 3.2 1.2–6.9 4/6 66.7
Muscle 2 1.1 0.1–3.8 1/2 50.0
Extra-Thoracic Lymph Node 64 34.2 27.5–41.5 18/64 28.1
Kidney 2 1.1 0.1–3.8 2/2 100.0
Nervous System 14 7.5 4.1–12.2 1/14c 7.1
Cardiac 20 10.7 6.7–16.0 3/20 15.0
Other Organs 9 4.8 2.2–8.9 6/9 66.7
 Testis 3 1.6 0.3–4.6 2/3 66.7
 Large intestine 1 0.5 0.0–2.9 1/1 100.0
 Stomach 2 1.1 0.1–3.8 2/2 100.0
 Thyroid 2 1.1 0.1–3.8 0/2 0.0
 Appendix 1 0.5 0.0–2.9 1/1 100.0
  1. a10 subjects with evidence of calcium stones by stone analysis for calcium-vitD involvement
  2. b4 subjects with arthralgia associated with Lofgren’s syndrome was included for bone-joint involvement
  3. c3 subjects with evidence of small fiber neuropathy by skin biopsy for nervous system involvement