Table 4 Changes in individual REVEAL components at ≥6-month time point
Component | n | Baseline score, mean (SD) | ≥6-month score, mean (SD) | Mean change (95% CI) | p-value |
|---|---|---|---|---|---|
WHO FC (as continuous) | 72 | 2.1 (0.7) | 2.8 (0.7) | −0.7 (−0.8, −0.5) | < 0.0001 |
SBP, mm Hg | 72 | 120.4 (17.1) | 117.9 (15.6) | −2.5 (−6.4, 1.4) | 0.0476 |
Heart rate, beats/min | 73 | 77.8 (12.1) | 77.0 (13.8) | −0.8 (−4.3, 2.8) | 0.5057 |
6-min walk test, m | 46 | 364.5 (133.3) | 406.3 (112.3) | 41.8 (14.5, 69.2) | 0.0003 |
BNP, pg/mL | 16 | 310.1 (350.2) | 152.5 (164.8) | −157.6 (− 336.3, −21.1) | 0.0229 |
NT-proBNP, pg/mL | 37 | 1121.1 (1497.4) | 590.6 (630.4) | −530.0 (− 972.0, −88.9) | 0.0014 |
DLCO, % predicted | 23 | 52.7 (18.0) | 50.8 (19.2) | −1.9 (− 1.6, 5.5) | 0.2753 |
mRAP, mm Hg | 12 | 7.9 (4.0) | 7.7 (2.6) | −0.3 (−1.6, 2.1) | 0.4939 |
PVR, WU | 13 | 11.5 (4.6) | 8.1 (3.4) | −3.4 (−6.5, −0.2) | 0.0033 |