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Table 2 Baseline characteristics of patients in the validated per protocol (VPP) population

From: Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial

 

CTRX (n = 104)

ABPC/SBT (n = 108)

p-value

Male/female, n (% male)

55/49 (53)

60/48 (56)

0.78*

Age, y

59.0 ± 21.6

63.2 ± 18.9

0.13

Comorbidities*

 Cancer

8 (8)

12 (11)

0.48*

 Hematological malignancy

2 (2)

0 (0)

0.24†

 Cardiovascular disease

7 (7)

12 (11)

0.34*

 Chronic lung disease

21 (20)

19 (18)

0.73*

 Bronchial asthma

11 (11)

10 (9)

0.82*

 COPD

6 (6)

6 (6)

1.00*

 Chronic liver disease

1 (1)

0 (0)

0.49†

 Chronic kidney disease

2 (2)

2 (2)

1.00†

Pneumonia severity index

66.3 ± 32.5

68.5 ± 26.7

0.60

 Class I, n (%)

26 (25)

20 (19)

0.63‡

 Class II, n (%)

35 (34)

36 (33)

 Class III, n (%)

20 (19)

38 (35)

 Class IV, n (%)

19 (18)

11 (10)

 Class V, n (%)

4 (4)

3 (3)

Performance status, n (%)

 0

93 (89)

98 (91)

0.76‡

 1

9 (9)

8 (7)

 2

2 (2)

1 (1)

 3

0 (0)

1 (1)

 4

0 (0)

0 (0)

Maximum body temperature, °C

 Before treatment

38.1 ± 0.9

38.1 ± 1.0

0.77

 Day of visit

38.0 ± 0.9

38.1 ± 1.0

0.77

Systolic blood pressure, mmHg

127.8 ± 20.9

132.0 ± 24.4

0.18

Diastolic blood pressure, mmHg

73.0 ± 16.2

73.3 ± 13.4

0.90

Pulse rate, beats/min

91.2 ± 17.2

89.2 ± 15.8

0.36

Respiration rate, breaths/min (n)

21.1 ± 4.9 (68)

22.0 ± 5.3 (77)

0.31

CRP, mg/dL

11.0 ± 7.1

12.5 ± 7.5

0.12

WBC, ×103/μL

11.7 ± 4.9

11.0 ± 5.3

0.37

Albumin, g/dL (n)

3.8 ± 0.5 (103)

3.8 ± 0.4 (106)

0.97

  1. CTRX Ceftriaxone, ABPC/SBT Ampicillin/sulbactam, CRP C-reactive protein, WBC White blood cell. Data are presented as mean ± standard deviation (SD) for continuous variables and number (%) for categorical variables. Comparisons were conducted using Student’s t-test unless otherwise indicated. *Chi-squared test. †Fisher exact test. ‡Mann–Whitney U test