An 8 week open-label interventional multicenter study to explore the lung clearance index as endpoint for clinical trials in cystic fibrosis patients ≥8 years of age, chronically infected with Pseudomonas aeruginosa

Table 2 Lung function parameters after visit 4 versus baseline

Patient #	Age	FEV₁ at baseline (% predicted)	dLCI in % of baseline	dFEV₁ in % of baseline	dCFU [/g]
1	17	82.6	29.8%	11.0%	−17,120
2	17	84.7	3.8%	10.6%	–
3	37	71.5	−42.4%	7.2%	−224,700
4	19	68.2	−24.6%	7.0%	–
5	19	115.5	−19.8%	4.4%	–
6	24	109.9	10,5%	2.7%	−12,200
7	35	77.8	−3.0%	2.1%	−12,640
8	37	79,5	6.7%	0.9%	−40
9	22	44.7	−24.1%	0.6%	20,800
10	18	65.9	−4.8%	0.0%	− 225,600
11	41	61.9	−4.6%	0.0%	− 8800
12	30	51.5	−15.6%	−1.0%	100
13	8	88.9	− 6.9%	−2.2%	732
14	43	101.1%	8.7%	−5.1%	14,000
15	34	67.9%	17.1%	−6.9%	−10,040
16	23	75.3%	4.8%	−12.5%	29,600
17	24	68.6%	36.2%	−13.0%	–

CFU colony forming units, d difference at week 4 versus baseline, FEV₁ forced expiratory volume in one second, LCI lung clearance index

ISSN: 1471-2466