Skip to main content

Table 1 Clinical characteristics in nonresolving acute respiratory distress syndrome (ARDS) patients undergoing transbronchial lung cryobiopsy (TBLC)

From: Transbronchial lung cryobiopsy may be of value for nonresolving acute respiratory distress syndrome: case series and systematic literature review

Case Age (years), gender Underly diseases ARDS severity Ventilation settings Guidance Freezing time Sample number and size Complication Finial pathology Management changes Outcome
1 39/F MS Severe PCV (PC 14 cmH2O, FiO2 90%, PEEP 11 cmH2O) and ECMO (4500 rpm, blood flow 6.3 L/min, gas flow 4 L/min, FiO2 100%) RP-EBUS 2.4 mm/4 s 2/20, 30 mm2 Severe bleeding Fibrotic phase of DAD with underly infection changes in antibiotic drugs and steroid discontinuation Died
2 68/M NS Severe PCV (PC 16 cmH2O, FiO2 40%, PEEP 6 cmH2O) and ECMO (3120 rpm, blood flow 3.86 L/min, gas flow 3.5 L/min, FiO2 100%) RP-EBUS 2.4 mm/4 s 3/12, 20, 35 mm2 Mild bleeding Proliferative phase of DAD with CMV inclusion initiation of high-dose steroid and antivirus treatment Rehab
3 62/F IGT Severe PCV (PC 24 cmH2O, FiO2 70%, PEEP 10 cmH2O) RP-EBUS 2.4 mm/4 s 4/9, 12, 16, 25 mm2 Mild bleeding Foreign body granulomas initiation of high-dose steroid and a determination of the aspiration etiology Rehab
4 65/F CA Severe PCV (PC 20 cmH2O, FiO2 100%, PEEP 8 cmH2O) RP-EBUS 2.4 mm/4 s 4/9, 12, 16, 25 mm2 Severe bleeding Fibrotic NSIP steroid discontinuation and transitioned to palliative measures Died
5 31/M   moderate HFNC (FiO2 40%, gas flow rate 60 L/min) RP-EBUS and CBCT 2.4 mm/4 s 4/9, 15, 24, 42 mm2 Mild bleeding COP initiation of high-dose steroid Rehab
  1. M man; F woman; MS multiple sclerosis; NS nephrotic syndrome; IGT impaired glucose tolerance; CA lung adenocarcinoma; PCV pressure control ventilation; PEEP positive end expiratory pressure; PC pressure control above PEEP; ECMO extracorporeal membrane oxygenation; RP-EBUS radial probe endobronchial ultrasound; CBCT cone beam computed tomography; DAD diffuse alveolar damage; HFNC high-flow nasal cannula oxygen therapy; CMV cytomegalovirus; NSIP non-specific interstitial pneumonia; COP cryptogenic organized pneumonia; Rehab rehabilitation