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Table 2 Characteristics of the included studies with nonresolving acute respiratory distress syndrome (ARDS) patients undergoing transbronchial lung cryobiopsy (TBLC)

From: Transbronchial lung cryobiopsy may be of value for nonresolving acute respiratory distress syndrome: case series and systematic literature review

Study / year

Number of patients

Ventilation support

Final pathology diagnosis

Management changes

Complications

Survivals

Dincer et al./2018

5

MV

5/5 (2 DAD, 2 OP and 1 IPS)

5/5

None

4/5

Cooley et al./2019

11

MV

9/11 (4DAD, 2COP and 3 others)

8/11

4 pneumothorax, 2 persistent air leak, 1 significant bleeding

6/11

Las Heras et al./2019

4

MV

4/4 (3 DAD and 1 other)

2/4

None

NA

Current study

5

MV and ECMO

5/5 (2 DAD and 3 others)

5/5

2 significant bleeding

3/5

Summary

25

23/25 (11/25 DAD)

20/25

4/25 pneumothorax, 3/25 significant bleeding, 2/25 persistent air leak

13/21

  1. MV mechanical ventilation; ECMO extracorporeal membrane oxygenation; DAD diffuse alveolar damage; IPS idiopathic pneumonia syndrome; OP organized pneumonia; COP cryptogenic organizing pneumonia; NA not available