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Table 3 Responsiveness of the different HRQL measures to changes in ACT—results of the regression analyses

From: How does the EQ-5D-5L perform in asthma patients compared with an asthma-specific quality of life questionnaire?

  N (%)β-coefficientp-value95% confidence intervals 
AQLQ change3 ≤ ∆ACT185 (49.9)0.63< 0.00010.4170.850
(T2–T1)0 < ∆ACT< 366 (17.8)0.030.824−0.1990.250
 ∆ACT = 041 (11.1)Ref. cat....
 −3 < ∆ACT< 050 (13.5)−0.140.226−0.3740.089
 ∆ACT≤–329 (7.8)−0.230.095−0.4940.040
AQLQ change3 ≤ ∆ACT66 (17.8)0.250.0210.0370.464
(T3–T2)0 < ∆ACT< 387 (23.5)0.030.776−0.1710.229
 ∆ACT = 054 (14.6)Ref. cat....
 −3 < ∆ACT< 093 (25.1)−0.340.0006−0.532− 0.145
 ∆ACT≤–371 (19.1)−0.84< 0.0001−1.047−0.632
EQ-5D index change3 ≤ ∆ACT185 (49.9)0.040.089−0.0060.090
(T2–T1)0 < ∆ACT< 366 (17.8)0.010.663−0.0390.061
 ∆ACT = 041 (11.1)Ref. cat....
 −3 < ∆ACT< 050 (13.5)0.010.637−0.0390.064
 ∆ACT≤–329 (7.8)−0.020.419−0.0840.035
EQ-5D index change3 ≤ ∆ACT66 (17.8)0.020.295−0.0220.071
(T3–T2)0 < ∆ACT< 387 (23.5)−0.010.691−0.0520.034
 ∆ACT = 054 (14.6)Ref. cat...
 −3 < ∆ACT< 093 (25.1)−0.020.398− 0.0600.024
 ∆ACT≤–371 (19.1)−0.080.0008−0.123−0.033
VAS change3 ≤ ∆ACT185 (49.9)5.820.0240.78210.850
(T2–T1)0 < ∆ACT< 366 (17.8)−1.620.540−6.8093.572
 ∆ACT = 041 (11.1)Ref. cat....
 −3 < ∆ACT< 050 (13.5)−5.290.054−10.6580.084
 ∆ACT≤–329 (7.8)−7.770.014−13.946−1.592
VAS change3 ≤ ∆ACT66 (17.8)5.960.0091.50710.423
(T3–T2)0 < ∆ACT< 387 (23.5)2.260.286−1.9006.424
 ∆ACT = 054 (14.6)Ref. cat....
 −3 < ∆ACT< 093 (25.1)−0.690.736−4.7263.340
 ∆ACT≤–371 (19.1)−8.97< 0.0001−13.298−4.650
  1. All results are adjusted for group (intervention vs. control), age, sex, smoking status, BMI, employed (yes/no), and HRQL at T0, T1, or T2 respectively. MID for ACT = 3. Abbreviations: ACT Asthma Control Test, AQLQ Asthma Quality of Life Questionnaire, Ref. cat. reference category, VAS Visual Analog Scale