Table 3 Responsiveness of the different HRQL measures to changes in ACT—results of the regression analyses

AQLQ change

3 ≤ ∆ACT

185 (49.9)

0.63

< 0.0001

0.417

0.850

(T2–T1)

0 < ∆ACT< 3

66 (17.8)

0.03

0.824

−0.199

0.250

∆ACT = 0

41 (11.1)

Ref. cat.

.

.

.

−3 < ∆ACT< 0

50 (13.5)

−0.14

0.226

−0.374

0.089

∆ACT≤–3

29 (7.8)

−0.23

0.095

−0.494

0.040

AQLQ change

3 ≤ ∆ACT

66 (17.8)

0.25

0.021

0.037

0.464

(T3–T2)

0 < ∆ACT< 3

87 (23.5)

0.03

0.776

−0.171

0.229

∆ACT = 0

54 (14.6)

Ref. cat.

.

.

.

−3 < ∆ACT< 0

93 (25.1)

−0.34

0.0006

−0.532

− 0.145

∆ACT≤–3

71 (19.1)

−0.84

< 0.0001

−1.047

−0.632

EQ-5D index change

3 ≤ ∆ACT

185 (49.9)

0.04

0.089

−0.006

0.090

(T2–T1)

0 < ∆ACT< 3

66 (17.8)

0.01

0.663

−0.039

0.061

∆ACT = 0

41 (11.1)

Ref. cat.

.

.

.

−3 < ∆ACT< 0

50 (13.5)

0.01

0.637

−0.039

0.064

∆ACT≤–3

29 (7.8)

−0.02

0.419

−0.084

0.035

EQ-5D index change

3 ≤ ∆ACT

66 (17.8)

0.02

0.295

−0.022

0.071

(T3–T2)

0 < ∆ACT< 3

87 (23.5)

−0.01

0.691

−0.052

0.034

∆ACT = 0

54 (14.6)

Ref. cat

.

.

.

−3 < ∆ACT< 0

93 (25.1)

−0.02

0.398

− 0.060

0.024

∆ACT≤–3

71 (19.1)

−0.08

0.0008

−0.123

−0.033

VAS change

3 ≤ ∆ACT

185 (49.9)

5.82

0.024

0.782

10.850

(T2–T1)

0 < ∆ACT< 3

66 (17.8)

−1.62

0.540

−6.809

3.572

∆ACT = 0

41 (11.1)

Ref. cat.

.

.

.

−3 < ∆ACT< 0

50 (13.5)

−5.29

0.054

−10.658

0.084

∆ACT≤–3

29 (7.8)

−7.77

0.014

−13.946

−1.592

VAS change

3 ≤ ∆ACT

66 (17.8)

5.96

0.009

1.507

10.423

(T3–T2)

0 < ∆ACT< 3

87 (23.5)

2.26

0.286

−1.900

6.424

∆ACT = 0

54 (14.6)

Ref. cat.

.

.

.

−3 < ∆ACT< 0

93 (25.1)

−0.69

0.736

−4.726

3.340

∆ACT≤–3

71 (19.1)

−8.97

< 0.0001

−13.298

−4.650