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Table 5 Mean change in HRQL scores stratified by GROC

From: How does the EQ-5D-5L perform in asthma patients compared with an asthma-specific quality of life questionnaire?

T1–T2
N = 371
Distinction between deterioration and improvementNo distinction
N = 371Large neg
n = 6
Mod. negn = 13Small neg
n = 43
No changen = 107Small posn = 52Mod. pos
n = 96
Large pos
n = 54
No change
n = 107
Small change
n = 95
Mod. change
n = 109
Large change
n = 60
AQLQ changeMean [CI]0.02
[− 0.25; 0.29]
−0.35 [− 0.69; − 0.01]−0.04 [− 0.2; 0.12]0.14 [0.05; 0.24]0.62 [0.40; 0.83]1.13 [0.99; 1.27]1.78 [1.58; 1.97]0.38 [0.32; 0.44]0.60 [0.49; 0.71]1.05
[0.92; 1.19]
1.62
[1.4; 1.83]
EQ-5D index changeMean [CI]0.04 [−0.35; 0.44]−0.07 [− 0.17; 0.03]−0.02 [− 0.06; 0.02]0.00 [− 0.02; 0.03]0.04 [0.00; 0.08]0.08 [0.06; 0.11]0.08 [0.05; 0.11]0.08 [0.06; 0.1]0.08 [0.06;0.11]0.11 [0.09;0.13]0.11 [0.08; 0.14]
VAS changeMean [CI]−6.67 [−16.98; 3.65]−9.62 [−22.24; 3.01]−7.14 [− 11.72; − 2.56]− 0.45 [−3.22; 2.32]9.54 [5.96; 13.12]17.52 [14.37;20.67]21.98 [18.10;25.87]9.42 [7.32; 11.51]12.2 [10.07;14.37]18.4
[15.7; 21.12]
20.6 [16.92;24.31]
T1–T3
N = 371
Distinction between deterioration and improvementNo distinction
Large neg
n = 3
Mod. negn = 18Small negn = 40No changen = 119Small posn = 63Mod. pos
n = 85
Large posn = 43No change
n = 119
Small change
n = 103
Mod. change
n = 103
Large change
n = 46
AQLQ changeMean [CI]−0.10
[−1.0; 0.77]
−0.03
[− 0.35; 0.29]
0.01
[− 0.17; 0.19]
0.34 [0.23; 0.45]0.73 [0.57; 0.90]1.17 [1.0; 1.35]1.62 [1.34; 1.91]0.53 [0.45; 0.61]0.69
[0.6; 0.79]
1.14
[1.02; 1.27]
1.57
[1.3; 1.84]
EQ-5D index change
Mean [CI]
−0.18
[−1.11; 0.76]
− 0.09 [− 0.22; 0.03]0.00 [− 0.04; 0.04]0.02
[− 0.01; 0.04]
0.04 [0.02; 0.07]0.06 [0.03; 0.09]0.10 [0.03; 0.16]0.09 [0.07; 0.11]0.08 [0.07; 0.1]0.12 [0.09; 0.14]0.15 [0.09; 0.2]
VAS changeMean [CI]−23.33 [−37.68;
−8.99]
−7.56
[−16.59; 1.48]
−4.88
[− 10.85; 1.10]
0.61
[− 2.16; 3.39]
7.40 [3.95; 10.85]17.07 [13.63;20.51]21.60 [17.12;26.1]9.6 [7.49; 11.79]12.3 [10.0; 14.6]18.1 [15.47;20.79]22.4 [18.49;26.25]
  1. Abbreviations: HRQL health-related quality of life, GROC Global Rating of Change, ACT Asthma Control Test, AQLQ Asthma Quality of Life Questionnaire, VAS Visual Analog Scale, CI 95% confidence interval, mod moderate, neg negative, pos positive