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Table 5 Mean change in HRQL scores stratified by GROC

From: How does the EQ-5D-5L perform in asthma patients compared with an asthma-specific quality of life questionnaire?

T1–T2

N = 371

Distinction between deterioration and improvement

No distinction

N = 371

Large neg

n = 6

Mod. negn = 13

Small neg

n = 43

No changen = 107

Small posn = 52

Mod. pos

n = 96

Large pos

n = 54

No change

n = 107

Small change

n = 95

Mod. change

n = 109

Large change

n = 60

AQLQ changeMean [CI]

0.02

[− 0.25; 0.29]

−0.35 [− 0.69; − 0.01]

−0.04 [− 0.2; 0.12]

0.14 [0.05; 0.24]

0.62 [0.40; 0.83]

1.13 [0.99; 1.27]

1.78 [1.58; 1.97]

0.38 [0.32; 0.44]

0.60 [0.49; 0.71]

1.05

[0.92; 1.19]

1.62

[1.4; 1.83]

EQ-5D index changeMean [CI]

0.04 [−0.35; 0.44]

−0.07 [− 0.17; 0.03]

−0.02 [− 0.06; 0.02]

0.00 [− 0.02; 0.03]

0.04 [0.00; 0.08]

0.08 [0.06; 0.11]

0.08 [0.05; 0.11]

0.08 [0.06; 0.1]

0.08 [0.06;0.11]

0.11 [0.09;0.13]

0.11 [0.08; 0.14]

VAS changeMean [CI]

−6.67 [−16.98; 3.65]

−9.62 [−22.24; 3.01]

−7.14 [− 11.72; − 2.56]

− 0.45 [−3.22; 2.32]

9.54 [5.96; 13.12]

17.52 [14.37;20.67]

21.98 [18.10;25.87]

9.42 [7.32; 11.51]

12.2 [10.07;14.37]

18.4

[15.7; 21.12]

20.6 [16.92;24.31]

T1–T3

N = 371

Distinction between deterioration and improvement

No distinction

Large neg

n = 3

Mod. negn = 18

Small negn = 40

No changen = 119

Small posn = 63

Mod. pos

n = 85

Large posn = 43

No change

n = 119

Small change

n = 103

Mod. change

n = 103

Large change

n = 46

AQLQ changeMean [CI]

−0.10

[−1.0; 0.77]

−0.03

[− 0.35; 0.29]

0.01

[− 0.17; 0.19]

0.34 [0.23; 0.45]

0.73 [0.57; 0.90]

1.17 [1.0; 1.35]

1.62 [1.34; 1.91]

0.53 [0.45; 0.61]

0.69

[0.6; 0.79]

1.14

[1.02; 1.27]

1.57

[1.3; 1.84]

EQ-5D index change

Mean [CI]

−0.18

[−1.11; 0.76]

− 0.09 [− 0.22; 0.03]

0.00 [− 0.04; 0.04]

0.02

[− 0.01; 0.04]

0.04 [0.02; 0.07]

0.06 [0.03; 0.09]

0.10 [0.03; 0.16]

0.09 [0.07; 0.11]

0.08 [0.07; 0.1]

0.12 [0.09; 0.14]

0.15 [0.09; 0.2]

VAS changeMean [CI]

−23.33 [−37.68;

−8.99]

−7.56

[−16.59; 1.48]

−4.88

[− 10.85; 1.10]

0.61

[− 2.16; 3.39]

7.40 [3.95; 10.85]

17.07 [13.63;20.51]

21.60 [17.12;26.1]

9.6 [7.49; 11.79]

12.3 [10.0; 14.6]

18.1 [15.47;20.79]

22.4 [18.49;26.25]

  1. Abbreviations: HRQL health-related quality of life, GROC Global Rating of Change, ACT Asthma Control Test, AQLQ Asthma Quality of Life Questionnaire, VAS Visual Analog Scale, CI 95% confidence interval, mod moderate, neg negative, pos positive