Skip to main content

Table 1 Characteristics of studies included in the meta-analysis Study

From: The association between cystatin C and COPD: a meta-analysis and systematic review

Author

Year

Study design

Country

Ethnicity

Sample

Sample size

Assay method

Cys C Concentration (mean±SD, mg/L)

Subjects(% men)

Age (mean±SD or median (range), year)

NOS score

Case

Control

Case

Control

SCOPD

AECOPD

Control

Qu et al [37]

2010

Case-control

China

Asian

serum

70

30

ELISA

SCOPD(70)1.76±0.62

0.98±0.51

62.3/NA/66.7

64.60±10.50

NA

63.50±9.20

6

Rokadia et al [38]

2012

Cross-sectional

USA

Caucasian

serum

374

5264

immunonephelometry

All(374)0.978±0.34;Emphysema(120)1.139±0.24;Chronic bronchitis(254)0.902±0.35

0.883±0.58

36.6/49.3

52.4

41.1

8

Sun et al [39]

2013

Case-control

China

Asian

serum

84

NA

immunonephelometry

SCOPD(30)0.95±0.23; AECOPD(54)1.12±0.26

NA

70.0/68.5/NA

64.17±10.03

66.98±8.07

NA

6

Zhang et al [27]

2014

Case-control

China

Asian

serum

129

122

immunonephelometry

SCOPD(129)0.115±0.05

0.105±0.03

100.0/NA/100.0

81.78± 6.68

NA

80.26±6.81

8

Zhang et al [29]

2014

Case-control

China

Asian

serum

392

151

immunonephelometry

All(392)1.04±0.21;SCOPD(299)1.03±0.21;AECOPD(93)1.09±0.22

0.84±0.18

96.1/73.1/55.0

65 (36-86)

65 (44-81)

63±6.00

8

Yoshizawa et al [40]

2015

Case-control

Japan

Asian

serum

108

73

immunonephelometry

SCOPD(108)1.2±0.4

0.9±0.2

83.3/NA/49.3

74.3±7.1

NA

71.8±7.3

9

Liu et al [41]

2015

Case-control

China

Asian

serum

132

36

ELISA

All(132)0.1287±0.0377;SCOPD(60)0.1254±0.0309;AECOPD(72)0.1315±0.0425

0.1084±0.0267

52.8/51.7/55.5

60-69

62-71

60-68

7

Zhang et al [42]

2015

Cohort

China

Asian

serum

90

90

immunonephelometry

AECOPD(90)1.31±0.30

0.87±0.13

NA/78.9/77.8

NA

63±7

62±7

7

Zhou et al [43]

2016

Case-control

China

Asian

serum

168

NA

immunonephelometry

SCOPD(60)0.94±0.22;AECOPD(108) 1.13±0.25

NA

70/67.6/NA

65.20±10.10

67.11±8.11

NA

6

Ni et al [44]

2017

Case-control

China

Asian

serum

90

45

immunonephelometry

All(90)0.1409±0.0197;SCOPD(45)0.1339±0.0154;AECOPD(45)0.1478±0.0212

0.1045±0.0209

54.4/53.3

58.1±5.4

56.9±4.9

7

Chen et al [45]

2017

Case-control

China

Asian

serum

95

20

ELISA

0.13299±0.01121

0.10617±0.02132

56.8/63.3

64.04±3.12

63.76±2.44

7

Cui et al [46]

2018

Case-control

China

Asian

serum

157

50

immunonephelometry

1.06±0.41

0.84±0.27

60.5/60

73.2±8.2

70.5 ± 4.7

7

Selda et al [31]

2018

Case-control

Turkey

Asian

serum

126

50

immunonephelometry

All(126)0.99±0.45;SCOPD(68)1.01±0.56;AECOPD(58)0.97±0.29

0.47±0.13

88.2/82.8/82.0

64.19±10.6

65.12±6.93

60.12±11.77

8

Amado et al [28]

2018

Cohort

Spain

Caucasian

serum

65

18

immunonephelometry

SCOPD(65)0.97±0.32

0.88±0.2

72/NA/55

67±7

NA

67±5

9

Dickson et al [30]

2019

Case-control

China

Asian

serum

###

NA

immunonephelometry

SCOPD(362)1.18±0.471;AECOPD(1637)1.21±0.47

NA

68.5/69.5/NA

92.97±9.83

72.51±10.27

NA

7

  1. Abbreviations: COPD Chronic obstructive pulmonary disease, Cys C Cystatin C, NOS Newcastle-Ottawa scale, ELISA enzyme-linked immunosorbent assay, AECOPD acute exacerbation COPD, SCOPD stable COPD