Thoracic perfusion of recombinant mutant human tumor necrosis factor (rmhTNF) can be considered as a good adjunct in the treatment of malignant pleural effusion caused by lung cancer

Table 2 Raw data and methodological quality of included trials

Studies	Region	Sequence generation	Allocation concealment	Blind	Outcome data	Selective outcome reporting	Other sources of bias	ITT	Risk of bias
Yuquan L 2005 [25]	Single center	–	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Do W 2005 [20]	Single center	Random number table (SPSS)	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Yanhao W 2006 [13]	Single center	Random number table (SPSS)	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Zhijun W [26]	Single center	–	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Shimeng F 2010 [22]	Single center	Random number table (SPSS)	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Hua Z 2010 [9]	Single center	Random number table (SPSS)	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Xiqiang W 2010 [24]	Single center	–	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Haiyan C 2015 [10]	Single center	Random number table (SAS)	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Jin L 2015 [12]	Single center	–	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias
Tao H 2016 [23]	Single center	Random number table (SPSS)	Insufficient	Clear	Yes	No	Unclear	Yes	Low risk of bias
Chun W 2016 [19]	Single center	Random number table (SPSS)	Insufficient	Clear	Yes	No	Unclear	Yes	Low risk of bias
Hua Z 2017 [21]	Single center	Random number table (SPSS)	Insufficient	Unclear	Yes	No	Unclear	Yes	Unclear risk of bias

ISSN: 1471-2466