Skip to main content

Table 3 Assessment of administration of included studies

From: Thoracic perfusion of recombinant mutant human tumor necrosis factor (rmhTNF) can be considered as a good adjunct in the treatment of malignant pleural effusion caused by lung cancer

StudyTrial group (N)Control Group (N)Interventions (Groups)Treatment cycleTermination of treatment
rmhTNF+cisplatinCisplatin alone
Yuquan L 2005 [25]1818rmhTNF 10 million units+NS 40 mL
Cisplatin 60 mg + NS 50 mL
Cisplatin 60 mg + NS 50 mL1/week> 2 cycles, or
pleural effusion disappeared
Do W 2005 [20]3131rmhTNF 15 million units+NS 20 mL
Cisplatin 30 mg/m2 + NS 20 mL
Cisplatin 40 mg/m2 + NS 20 mL2–3/week> 2 cycles, or
pleural effusion disappeared
Yanhao W 2006 [13]2828rmhTNF 15 million units+NS 40 mL
Cisplatin 60 mg + NS 50 mL
Cisplatin 60 mg + NS 50 mL1/week> 2 cycles, or
pleural effusion disappeared
Zhijun W [26]5331rmhTNF 1.5 million units+NS 40 mL
Cisplatin 60 mg + NS 50 mL
Cisplatin 60 mg + NS 50 mL1/week> 2 cycles, or
pleural effusion disappeared
Shimeng F 2010 [22]4330rmhTNF 15 million units+NS 20 mL
Cisplatin 30 mg/m2 + NS 20 mL
Cisplatin 40 mg/m2 + NS 20 mL2–3/week> 2 cycles, or
pleural effusion disappeared
Hua Z 2010 [9]3424rmhTNF 1 million units+NS 20 mL
Cisplatin 40 mg/m2 + NS 20 mL
Cisplatin 40 mg/m2 + NS 20 mL1/week> 2 cycles, or
pleural effusion disappeared
Xiqiang W 2010 [24]2331rmhTNF 2 million units+NS 40 mL
Cisplatin 40 mg + NS 40 mL
Cisplatin 40 mg + NS 40 mL1/week> 2 cycles, or
pleural effusion disappeared
Haiyan C 2015 [10]2627rmhTNF 5 million units+NS 25 mL
Cisplatin 40-60 mg + NS 50 mL
Cisplatin 40-60 mg + NS 25 mL1/week> 2 cycles, or
pleural effusion disappeared
Jin L 2015 [12]2629rmhTNF 15 × 106  units+NS 20 mL
Cisplatin 40 mg/m2 + NS 20 mL
Cisplatin 40 mg/m2 + NS 20 mL1/week> 4 cycles, or
pleural effusion disappeared
Tao H 2016 [23]3030rmhTNF 2 × 106  units+NS 20 mL
Cisplatin 30 mg/m2 + NS 20 mL
Cisplatin 30 mg/m2 + NS 20 mL1/week> 4 cycles, or
pleural effusion disappeared
Chun W 2016 [19]3232rmhTNF 3 million units+NS 60 mL
Cisplatin 40 mg + NS 60 mL
Cisplatin 40 mg + NS 60 mL1/week> 2 cycles, or
pleural effusion disappeared
Hua Z 2017 [21]2118rmhTNF 1 million units+NS 20 mL
Cisplatin 40 mg/m2 + NS 20 mL
Cisplatin 40 mg/m2 + NS 20 mL1/week> 4 cycles, or
pleural effusion disappeared
  1. N numbers of patients, rmhTNF recombinant mutant human tumor necrosis factor injection, NS normal saline