Table 5 Moderation of prediction of clinically relevant improvement in CCQ score by condition: Logistic regression analyses
|  |  |  | 12-month follow-up (N = 902) | 24-month follow-up (N = 728) | ||
|---|---|---|---|---|---|---|
Model | Predictor | Value | Odds ratio (95% CI) | p-value | Odds ratio (95% CI) | p-value |
Step 1 | Gender | Female vs Male | 1.28 (0.94–1.74) | 0.12 |  |  |
Age | Each year |  |  | 0.96 (0.94–0.98) | < 0.001 | |
Low education | Yes vs No | 1.34 (0.98–1.82) | 0.06 |  |  | |
Dyspnea - MRC score > 2 | Yes vs No | 1.84 (1.33–2.53) | < 0.001 | 1.61 (1.03–2.51) | 0.04 | |
Major cardiovascular disease | Yes vs No |  |  | 1.63 (0.86–3.08) | 0.13 | |
Hypertension | Yes vs No |  |  | 1.00 (0.60–1.66) | 1.00 | |
Depression | Yes vs No |  |  | 1.33 (0.67–2.66) | 0.42 | |
Charlson co-morbidity index | Each point | 1.10 (0.98–1.24) | 0.12 | 1.12 (0.89–1.41) | 0.34 | |
Condition | Intervention vs Control | 0.72 (0.53–0.98) | 0.04 | 0.90 (0.59–1.36) | 0.61 | |
Step 2 (12-month) | Condition*Gender | 1.85 (1.00–3.44) | 0.05 |  |  | |
Step 2A (24-month) | Condition*Age |  |  | 0.98 (0.94–1.02) | 0.25 | |
Step 2B (24-month) | Condition*Dyspnea - MRC score > 2 |  |  | 1.08 (0.46–2.57) | 0.86 | |
Step 2C (24-month) | Condition*Depression |  |  | 0.56 (0.16–1.97) | 0.37 | |