Table 3 Diagnostic performance of pleural IL-27, ADA, and IFN-γ in differentiating between patients with tuberculous pleural effusion (TPE) and those with non-TPEs in the Beijing cohort (n = 154)
Age | Variable | Cut-off value | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PLR | NLR | PPV | NPV |
|---|---|---|---|---|---|---|---|---|---|
≤40 | ADA | 21.4 U/L | 1.000 (0.884 to 1.000) | 100.0 (85.8 to 100.0) | 100.0 (54.1 to 100.0) | – | 0 | 100.0 | 100.0 |
IFN-γ | 116.1 ng/L | 0.958 (0.815 to 0.998) | 91.7 (73.0 to 99.0) | 100.0 (54.1 to 100.0) | – | 0.1 (0 to 0.3) | 100.0 | 75.0 (44.3 to 91.9) | |
IL-27 | 591.4 ng/L | 0.979 (0.848 to 1.000) | 95.8 (78.9 to 99.9) | 100.0 (54.1 to 100.0) | – | 0 (0 to 0.3) | 100.0 | 85.7 (46.8 to 97.6) | |
>40 | ADA | 21.4 U/L | 0.817 (0.737 to 0.880) | 77.8 (57.7 to 91.4) | 85.6 (77.0 to 91.9) | 5.4 (3.2 to 9.1) | 0.3 (0.1 to 0.5) | 60.0 (47.0 to 71.7) | 93.3 (87.2 to 96.6) |
IFN-γ | 116.1 ng/L | 0.919* (0.856 to 0.960) | 88.9 (70.8 to 97.6) | 94.9 (88.4 to 98.3) | 17.2 (7.3 to 40.9) | 0.1 (0 to 0.3) | 82.8 (66.9 to 91.9) | 96.8 (91.3 to 98.9) | |
IL-27 | 591.4 ng/L | 0.976† (0.932 to 0.995) | 96.3 (81.0 to 99.9) | 99.0 (94.4 to 100.0) | 93.4 (13.3 to 657.4) | 0 (0 to 0.3) | 96.3 (78.7 to 99.5) | 99.0 (93.3 to 99.8) |