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Table 3 Diagnostic performance of pleural IL-27, ADA, and IFN-γ in differentiating between patients with tuberculous pleural effusion (TPE) and those with non-TPEs in the Beijing cohort (n = 154)

From: Influence of age on the diagnostic accuracy of soluble biomarkers for tuberculous pleural effusion: a post hoc analysis

AgeVariableCut-off valueAUC (95% CI)Sensitivity (%)Specificity (%)PLRNLRPPVNPV
≤40ADA21.4 U/L1.000 (0.884 to 1.000)100.0 (85.8 to 100.0)100.0 (54.1 to 100.0)0100.0100.0
IFN-γ116.1 ng/L0.958 (0.815 to 0.998)91.7 (73.0 to 99.0)100.0 (54.1 to 100.0)0.1 (0 to 0.3)100.075.0 (44.3 to 91.9)
IL-27591.4 ng/L0.979 (0.848 to 1.000)95.8 (78.9 to 99.9)100.0 (54.1 to 100.0)0 (0 to 0.3)100.085.7 (46.8 to 97.6)
>40ADA21.4 U/L0.817 (0.737 to 0.880)77.8 (57.7 to 91.4)85.6 (77.0 to 91.9)5.4 (3.2 to 9.1)0.3 (0.1 to 0.5)60.0 (47.0 to 71.7)93.3 (87.2 to 96.6)
IFN-γ116.1 ng/L0.919* (0.856 to 0.960)88.9 (70.8 to 97.6)94.9 (88.4 to 98.3)17.2 (7.3 to 40.9)0.1 (0 to 0.3)82.8 (66.9 to 91.9)96.8 (91.3 to 98.9)
IL-27591.4 ng/L0.976† (0.932 to 0.995)96.3 (81.0 to 99.9)99.0 (94.4 to 100.0)93.4 (13.3 to 657.4)0 (0 to 0.3)96.3 (78.7 to 99.5)99.0 (93.3 to 99.8)
  1. *p < 0.05, †p < 0.05, compared with ADA using the z statistic, respectively. ADA adenosine deaminase; AUC area under the curve; IFN interferon; IL interleukin; NLR negative likelihood ratio; NPV negative predictive value; PLR positive likelihood ratio; PPV positive predictive value