Table 4 Diagnostic performance of pleural ADA, IFN-γ, and IL-27 in differentiating between patients with tuberculous pleural effusion (TPE) and those with non-TPEs in the Wuhan cohort (n = 120)
Variable | Cut-off value | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PLR | NLR | PPV | NPV | |
|---|---|---|---|---|---|---|---|---|---|
≤40 | ADA | 21.4 U/L p < 0.001 | 1.000 (0.832 to 1.000) | 100.0 (76.8 to 100.0) | 100.0 (54.1 to 100.0) | – | 0 | 100.0 | 100.0 |
IFN-γ | 116.1 ng/L p < 0.001 | 1.000 (0.832 to 1.000) | 100.0 (76.8 to 100.0) | 100.0 (54.1 to 100.0) | – | 0 | 100.0 | 100.0 | |
IL-27 | 591.4 ng/L p < 0.001 | 1.000 (0.832 to 1.000) | 100.0 (76.8 to 100.0) | 100.0 (54.1 to 100.0) | – | 0 | 100.0 | 100.0 | |
>40 | ADA | 21.4 U/L p < 0.001 | 0.845 (0.759 to 0.910) | 83.3 (65.3 to 94.4) | 85.7 (75.3 to 92.9) | 5.8 (3.2 to 10.6) | 0.2 (0.1 to 0.4) | 71.4 (57.9 to 81.9) | 92.3 (84.3 to 96.4) |
IFN-γ | 116.1 ng/L p < 0.001 | 0.936* (0.868 to 0.975) | 90.0 (73.5 to 97.9) | 97.1 (90.1 to 99.7) | 31.5 (8.0 to 124.1) | 0.1 (0 to 0.3) | 93.1 (77.4 to 98.2) | 95.8 (88.6 to 98.5) | |
IL-27 | 591.4 ng/L p < 0.001 | 0.976† (0.924 to 0.996) | 96.7 (82.8 to 99.9) | 98.6 (92.3 to 100.0) | 67.7 (9.7 to 474.2) | 0 (0 to 0.2) | 96.7 (80.5 to 99.5) | 98.6 (90.9 to 99.8) |