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Table 4 Diagnostic performance of pleural ADA, IFN-γ, and IL-27 in differentiating between patients with tuberculous pleural effusion (TPE) and those with non-TPEs in the Wuhan cohort (n = 120)

From: Influence of age on the diagnostic accuracy of soluble biomarkers for tuberculous pleural effusion: a post hoc analysis

 VariableCut-off valueAUC (95% CI)Sensitivity (%)Specificity (%)PLRNLRPPVNPV
≤40ADA21.4 U/L
p < 0.001
1.000 (0.832 to 1.000)100.0 (76.8 to 100.0)100.0 (54.1 to 100.0)0100.0100.0
IFN-γ116.1 ng/L
p < 0.001
1.000 (0.832 to 1.000)100.0 (76.8 to 100.0)100.0 (54.1 to 100.0)0100.0100.0
IL-27591.4 ng/L
p < 0.001
1.000 (0.832 to 1.000)100.0 (76.8 to 100.0)100.0 (54.1 to 100.0)0100.0100.0
>40ADA21.4 U/L
p < 0.001
0.845 (0.759 to 0.910)83.3 (65.3 to 94.4)85.7 (75.3 to 92.9)5.8 (3.2 to 10.6)0.2 (0.1 to 0.4)71.4 (57.9 to 81.9)92.3 (84.3 to 96.4)
IFN-γ116.1 ng/L
p < 0.001
0.936* (0.868 to 0.975)90.0 (73.5 to 97.9)97.1 (90.1 to 99.7)31.5 (8.0 to 124.1)0.1 (0 to 0.3)93.1 (77.4 to 98.2)95.8 (88.6 to 98.5)
IL-27591.4 ng/L
p < 0.001
0.976† (0.924 to 0.996)96.7 (82.8 to 99.9)98.6 (92.3 to 100.0)67.7 (9.7 to 474.2)0 (0 to 0.2)96.7 (80.5 to 99.5)98.6 (90.9 to 99.8)
  1. *p < 0.05, †p < 0.05, compared with ADA using the z statistic, respectively. ADA adenosine deaminase; AUC area under the curve; IFN interferon; IL interleukin; NLR negative likelihood ratio; NPV negative predictive value; PLR positive likelihood ratio; PPV positive predictive value