Table 1 Discovery population characteristics per cohort
From: A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease
Study | Discovery cohorts | Replication cohorts | ||||||
|---|---|---|---|---|---|---|---|---|
ERF | RS-I-4 | RS-E5 | RS-III-2 | LLDEEP | FINRISK97 | DILGOM | PIVUS | |
N | 609 | 2777 | 686 | 1485 | 717 | 6898 | 4600 | 854 |
Age, mean (sd) | 49.0 (13.3) | 74.8 (6.5) | 68.4 (5.7) | 62.8 (5.8) | 46.0 (14.3) | 48.0 (13.1) | 52.3 (13.5) | 70 (0) |
Women, % (n) | 55.8 (340) | 58.2 (1615) | 57.6 (395) | 57.8 (859) | 56.3 (404) | 51.6 (3561) | 53.4 (2458) | 48.2 (412) |
COPD cases, % (n) | 10.0 (61) | 12.1 (336) | 10.3 (71) | 9.0 (134) | 13.8 (99) | 0.6 (43) | 0.8 (35) | NA |
FEV1/FVC, mean (sd), % of all | NA | 0.73 (0.08), 48.8 | 0.76 (0.07), 91.3 | 0.77 (0.07), 91.9 | 0.77 (0.08), 100 | NA | NA | 0.76 (0.11), 100 |
BMI, mean (sd) | 27.2 (4.85) | 27.4 (4.1) | 27.8 (4.3) | 27.4 (4.5) | 25.4 (4.1) | 26.6 (4.5) | 27.2 (4.8) | 27.1 (4.26) |
Current smokers, % (n) | 43.3 (264) | 12.6 (349) | 9.5 (65) | 13.7 (203) | 20.5 (147) | 23.9 (1648) | 17.6 (810) | 10.2 (87) |
Ex-smokers, % (n) | 30.0 (183) | 56.1 (1559) | 57.0 (391) | 50.2 (746) | NA | 22.9 (1577) | 26.3 (1210) | 41.5 (354) |
Never smokers, % (n) | 26.6 (162) | 31.3 (869) | 33.5 (230) | 36.1 (536) | 79.4 (570) | 53.2 (3673) | 56.1 (2580) | 48.2 (412) |
Pack-years of smoking, mean (sd), % of alla | 24.9(20.4) 72.7 | 24.2 (23.4), 64.7 | 22.0 (20.8) 66.3 | 19.5 (20.3) 63.8 | NA | NA | NA | NA |
LLM users, % (n) | 12.3 (75) | 22.4 (621) | 32.5 (223) | 22.2 (329) | 3.9 (28) | 3.4 (237) | 15.7 (721) | 16.5 (141) |