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Table 4 Results of the bi-directional MR approach on GlycA and COPD

From: A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease

Model Exposure Outcome R2 nSNP Method β SE P-value
1 GlycA COPD 2.30 9 Inverse variance weighted 0.001 0.027 0.97
Weighted median −0.009 0.029 0.76
Weighted mode −0.028 0.039 0.49
Simple mode −0.013 0.046 0.79
MR Egger −0.140 0.147 0.37
2 COPD GlycA 1.72 8 Inverse variance weighted 0.306 0.090 0.00068
Weighted median 0.348 0.115 0.0024
Weighted mode 0.378 0.150 0.04
Simple mode 0.359 0.157 0.06
MR Egger 0.412 0.624 0.53
  1. R2 - the explained variance in the exposure by applied genetic risk score; nSNP - number of SNPs used to construct the genetic risk score; β - the weighted effect of the genetic risk score of exposure on outcome; SE standard error; Significance threshold = P-value < 0.05. The Egger regression is a test to check the assumption of the instrument strength being independent of the direct effect to the outcome and should be P > 0.05