Fig. 4

Pulmonary and cerebellar histology. Histopathological characteristics supporting a diagnosis of GLILD: a the core biopsy of pulmonary parenchyma showing a reticular pattern of fibrosis and interstitial lymphocytic infiltration (H & E, × 100 magnification); b at higher magnification, the lymphocytes can be seen to form aggregates giving a nodular appearance. On CD3 immunostaining these lymphocytes proved to be of predominantly T-cell lineage (H & E, × 400); c the cerebellar biopsy from the same patient 10 years previously showing lymphocytic infiltration (red dot) with a similar pattern to that seen in the lung biopsy (H & E, × 100)