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Table 3 Levels of trans-organ differences in inflammatory cytokines and cell free DNA (cf-DNA)

From: Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis

   Group 0 h 3 h 5 h p
TNF-a (ng x L−1) Transpulmonary Prot-V − 9222 ± 15,097 − 1293 ± 3383 − 284 ± 645 0.17
Control −13,878 ± 10,454 − 3819 ± 1832 − 477 ± 979  
Transhepatic Prot-V 4919 ± 6573 1275 ± 3394 375 ± 664 0.91
Control 7531 ± 18,933 3638 ± 4823 − 459 ± 1589  
Transcerebral Prot-V 2519 ± 6600 369 ± 1749 541 ± 648 0.24
Control 2154 ± 4868 1560 ± 6843 528 ± 977  
Transsplanchnic Prot-V 5195 ± 11,969 −34 ± 2080 −27 ± 521 0.22
Control 4978 ± 13,845 672 ± 968 830 ± 1829  
IL-6 (ng x L−1) Transpulmonary Prot-V 33 ± 150 990 ± 470 493 ± 424 0.03*
Control 118 ± 285 1753 ± 1263 2172 ± 632  
Transhepatic Prot-V 17 ± 105 − 194 ± 258 −49 ± 220 0.19
Control −21 ± 65 − 500 ± 282 − 281 ± 242  
Transcerebral Prot-V 21 ± 183 −62 ± 762 −14 ± 499 0.43
Control −16 ± 296 −84 ± 732 − 450 ± 557  
Transsplanchnic Prot-V −32 ± 174 − 711 ± 547 − 406 ± 484 0.14
Control −126 ± 256 − 1100 ± 1264 − 1646 ± 2600  
IL-10 (ng x L−1) Transpulmonary Prot-V −70 ± 81 −30 ± 17 −26 ± 15 0.18
Control −138 ± 101 −138 ± 39 −5 ± 100  
Transhepatic Prot-V −313 ± 298 −70 ± 63 −5 ± 32 0.31
Control − 265 ± 221 −29 ± 109 90 ± 174  
Transcerebral Prot-V 110 ± 95 32 ± 18 31 ± 20 0.18
Control 125 ± 83 73 ± 80 34 ± 133  
Transsplanchnic Prot-V 428 ± 264 91 ± 60 27 ± 30 0.36
Control 344 ± 174 74 ± 68 61 ± 118  
cf-DNA (μg x mL−1) Transpulmonary Prot-V 0.02 ± 0.16 0.01 ± 0.14 0.03 ± 0.17 0.6
Control 0.01 ± 0.03 −0.04 ± 0.08 −0.17 ± 0.39  
Transhepatic Prot-V 0.03 ± 0.15 −0.01 ± 0.04 −0.01 ± 0.06 0.03*
Control −0.01 ± 0.03 0.04 ± 0.09 0.12 ± 0.04  
Transcerebral Prot-V −0.01 ± 0.08 0.01 ± 0.03 0.01 ± 0.03 0.6
Control −0.01 ± 0.03 0.03 ± 0.03 −0.01 ± 0.05  
Transsplanchnic Prot-V −0.02 ± 0.07 0.01 ± 0.04 0.02 ± 0.07 0.51
Control −0.01 ± 0.02 0.01 ± 0.02 0.01 ± 0.05  
  1. Values are given as mean ± SD. P-values are results of group effect in the analysis of variance (ANOVA) for repeated measures. * denotes p < 0.05. TNF-α-tumor necrosis factor alpha, IL-6-interleukin 6, IL-10-interleukin 10. Transpulmonary: the difference in plasma levels between the artery and the hepatic vein, transhepatic: the difference between the hepatic vein and the portal vein, transsplanchnic: the difference between the portal vein and the artery, transcerebral: the difference between the jugular bulb and the artery