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Fig. 4 | BMC Pulmonary Medicine

Fig. 4

From: LncRNA PCGEM1 accelerates non-small cell lung cancer progression via sponging miR-433-3p to upregulate WTAP

Fig. 4

PCGEM1 promotes NSCLC progression via miR-433-3p/WTAP axis. a, b The interference efficiency of miR-433-3p and the overexpression efficiency of WTAP were tested through qRT-PCR in NCI-H1299 and NCI-H1650 cells which transfected with miR-433-3p inhibitor or pcDNA3.1-WTAP. c, d EdU and CCK-8 experiments were utilized to measure the influence of miR-433-3p knockdown or WTAP overexpression on the inhibited cell proliferation which caused by PCGEM1 depletion. e The cell apoptosis ability which was restrained by PCGEM1 depletion was tested when miR-433-3p was inhibited or WTAP was up-regulated through flow cytometry analysis. f, g Cell migration and invasion inhibited by silenced PCGEM1 were evaluated after knockdown of miR-433-3p or overexpression of WTAP in NCI-H1299 and NCI-H1650 cells. **P < 0.01

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