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Table 2 Meta-regression analysis coefficients for TNF-α levels

From: Association between tumor necrosis factor alpha and obstructive sleep apnea in adults: a meta-analysis update

Covariates Elements Coefficient Standard Error t P 95% Confidence Interval
Sample size 0.01095 0.00551 1.99000 0.05300 −0.00015 0.02205
BMI 0.96000 0.34400 −0.25631 0.72067 0.96000 0.34400
Age 0.79053 0.32494 2.43000 0.01900 0.13607 1.44500
NOS −0.57894 0.30767 −1.88000 0.06600 −1.19861 0.04073
Development −1.83779 1.08681 −1.69000 0.09800 −4.02674 0.35115
regions America −1.15015 1.41992 −0.81000 0.42200 −4.01001 1.70972
Asia −0.18814 1.01291 −0.19000 0.85300 −2.22825 1.85196
Europe
Severity All −0.18343 1.27352 −0.14000 0.88600 −2.74843 2.38157
mild −0.45801 1.38464 −0.33000 0.74200 −3.24681 2.33079
moderate −0.81363 1.51188 −0.54000 0.59300 −3.85871 2.23145
moderate to severe −0.20049 1.32277 −0.15000 0.88000 −2.86469 2.46371
severe −0.29741 1.21544 −0.24000 0.80800 −2.74542 2.15061
mild to moderate
Method CLIA 0.21982 2.64027 0.08000 0.93400 −5.09796 5.53759
ELISA −3.70431 1.97035 −1.88000 0.06700 −7.67281 0.26418
ECLIA
Specimen Exhaled breath condensate 2.90545 2.75026 1.06000 0.29600 −2.63385 8.44475
PBMC −3.25580 3.41251 −0.95000 0.34500 −10.12894 3.61734
Pharyngeal lavage 0.79203 2.68878 0.29000 0.77000 −4.62345 6.20751
Plasma −0.27113 2.43064 −0.11000 0.91200 −5.16669 4.62444
Saliva 0.32275 2.90335 0.11000 0.91200 −5.52490 6.17041
Serum 0.60803 2.45687 0.25000 0.80600 −4.34035 5.55641
Gingival crevicular fluid
Gender −0.18789 0.35411 −0.53000 0.59800 −0.90109 0.52531
All 9.10716 4.37081 2.08000 0.04300 0.30389 17.91043
  1. Abbreviations: NOS Newcastle-Ottawa Scale, CLIA chemiluminescence analysis, ECLIA electrochemiluminescence immunoassay, ELISA enzyme linked immunosorbent assay, PBMC peripheral blood mononuclear cell