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Table 3 Comparison of Clinical Features Between Concave Pattern and Non-concave Pattern of Flow-volume Curve

From: Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis

  Concave pattern (n = 72) Non-concave pattern (n = 58) p value
Age, years 69 (63–75) 73 (66–77) 0.034
Gender (male/female) 58 (80.6%)/14 (19.4%) 46 (79.3%)/12 (20.7%) 0.860*
BMI, kg/m2 23.9 (22.1–26.5) 21.1 (19.8–23.5) < 0.001
Pack-years 30 (4–46) 25 (1–47) 0.558
FVC %pred., % 79.7 (68.4–92.9) 68.1 (59.1–86.2) 0.011
FEV1%pred., % 75.9 (66.2–89.2) 76.9 (64.1–92.8) 0.912
DLCO %pred., % 70.8 (53.8–84.0)** 67.7 (46.1–86.9)*** 0.330
CPI 28.7 (18.7–40.9)** 35.8 (18.3–50.3)*** 0.039
KL-6, U/ml 956 (648–1476)**** 979 (565–1544) 0.919
GAP stage 1 (1–2)** 2 (1–2) *** 0.033
  1. Data are presented as number or median (interquartile range)
  2. p values derived by Mann–Whitney U test. *p values derived by chi-square test
  3. **n = 70, ***n = 54, and ****n = 71
  4. BMI body mass index, FVC forced vital capacity, FEV1 forced expiratory volume in 1 s, DLCO diffusing capacity of the lungs for carbon monoxide, CPI composite physiologic index, KL-6 Krebs von den Lungen-6, GAP gender, age, and physiology