Skip to main content

Table 4 Comparison of Clinical Features Mixed Convex Pattern and Concave Pattern of Flow-volume Curve

From: Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis

 

A group

(n = 47)

B group

(n = 25)

C group

(n = 46)

D group

(n = 12)

p value

Age, years

68 (63–76)

69 (64–75)

73 (69–78)

71 (63–75)

0.104

Gender (male/female)

35/12

23/2

35/11

11/1

0.203*

BMI, kg/m2

23.6 (21.4–26.0)

25.4 (23.1–29.3)

20.8 (19.5–23.5)

23.0 (20.7–25.3)

< 0.001

Pack-years

27 (0–40)

40 (22–56)

19 (0–44)

38 (8–70)

0.064

FVC %pred., %

81.4 (68.2–98.4)

76.2 (67.1–86.7)

67.0 (57.9–84.4)

81.2 (65.1–98.8)

0.018

FEV1%pred., %

81.1 (69.9–93.8)

68.2 (64.8–80.0)

76.3 (65.2–91.4)

78.2 (63.8–98.8)

0.103

DLCO %pred., %

73.8 (53.1–86.6) **

69.6 (55.1–82.4)

68.8 (46.2–90.2)***

71.3 (43.2–77.7)

0.812

CPI

27.3 (19.7–40.7)**

31.1 (14.6–41.3)

35.8 (17.1–49.9)***

29.3 (21.7–49.8)

0.226

KL-6, U/ml

935 (686–1568)

960 (467–1519)

1070 (502–1776)

918 (652–1088)

0.883

GAP stage

1 (1–2)**

1 (1–2)

2 (1–-2)***

2 (1–2)

0.125

  1. Data are presented as number or median (interquartile range)
  2. p values derived by Kruskal-Wallis test. *p values derived by chi-square test
  3. **n = 45, and ***n = 42
  4. A group, the patients with the convex/concave pattern of flow volume curve; B group, the non-convex/concave pattern; C group, the convex/non-concave pattern; D group, the non-convex/non-concave pattern
  5. BMI body mass index, FVC forced vital capacity, FEV1 forced expiratory volume in 1 s, DLCO diffusing capacity of the lungs for carbon monoxide, CPI composite physiologic index, KL-6 Krebs von den Lungen-6, GAP gender, age, and physiology