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Table 4 Comparison of Clinical Features Mixed Convex Pattern and Concave Pattern of Flow-volume Curve

From: Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis

  A group
(n = 47)
B group
(n = 25)
C group
(n = 46)
D group
(n = 12)
p value
Age, years 68 (63–76) 69 (64–75) 73 (69–78) 71 (63–75) 0.104
Gender (male/female) 35/12 23/2 35/11 11/1 0.203*
BMI, kg/m2 23.6 (21.4–26.0) 25.4 (23.1–29.3) 20.8 (19.5–23.5) 23.0 (20.7–25.3) < 0.001
Pack-years 27 (0–40) 40 (22–56) 19 (0–44) 38 (8–70) 0.064
FVC %pred., % 81.4 (68.2–98.4) 76.2 (67.1–86.7) 67.0 (57.9–84.4) 81.2 (65.1–98.8) 0.018
FEV1%pred., % 81.1 (69.9–93.8) 68.2 (64.8–80.0) 76.3 (65.2–91.4) 78.2 (63.8–98.8) 0.103
DLCO %pred., % 73.8 (53.1–86.6) ** 69.6 (55.1–82.4) 68.8 (46.2–90.2)*** 71.3 (43.2–77.7) 0.812
CPI 27.3 (19.7–40.7)** 31.1 (14.6–41.3) 35.8 (17.1–49.9)*** 29.3 (21.7–49.8) 0.226
KL-6, U/ml 935 (686–1568) 960 (467–1519) 1070 (502–1776) 918 (652–1088) 0.883
GAP stage 1 (1–2)** 1 (1–2) 2 (1–-2)*** 2 (1–2) 0.125
  1. Data are presented as number or median (interquartile range)
  2. p values derived by Kruskal-Wallis test. *p values derived by chi-square test
  3. **n = 45, and ***n = 42
  4. A group, the patients with the convex/concave pattern of flow volume curve; B group, the non-convex/concave pattern; C group, the convex/non-concave pattern; D group, the non-convex/non-concave pattern
  5. BMI body mass index, FVC forced vital capacity, FEV1 forced expiratory volume in 1 s, DLCO diffusing capacity of the lungs for carbon monoxide, CPI composite physiologic index, KL-6 Krebs von den Lungen-6, GAP gender, age, and physiology