Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis

Table 8 Results of Cox’s Hazard Regression Analysis for Predictors of Mortality Adjusted by Age, Gender, BMI, and Pack-year

	HR	95% CI	p value
C group (vs non-C group)	2.19	1.07–4.49	0.032
FVC %pred., %	0.97	0.94–0.99	0.002
FEV₁%pred., %	0.99	0.97–1.01	0.289
DL_CO %pred., %	0.97	0.95–0.99	0.002
CPI	1.05	1.02–1.08	< 0.001
GAP stage	1.93	0.98–3.74	0.057
KL-6, U/ml	1.00	1.00–1.00	0.360
%HA, %	1.26	1.13–1.40	< 0.001
%sLAA, %	0.98	0.90–1.06	0.665
Convex pattern (vs Non-convex pattern)	1.67	0.84–3.50	0.143
Concave pattern (vs Non-concave pattern)	0.56	0.29–1.10	0.091

HR hazard ratio, CI confidence interval, %HA computed-tomography-derived %honeycombing area, %sLAA computed-tomography-derived %subtracted low attenuation area, BMI body mass index, FVC forced vital capacity, FEV₁ forced expiratory volume in 1 s, DL_CO diffusing capacity of the lungs for carbon monoxide, CPI composite physiologic index, KL-6 Krebs von den Lungen-6, GAP gender, age, and physiology

ISSN: 1471-2466