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Table 1 Laboratory test

From: Double anti-PL-7 and anti-MDA-5 positive Amyopathic Dermatomyositis with rapidly progressive interstitial lung disease in a Hispanic patient

Test name

Value (reference range)

Hematology

 White blood count

9.1 103/uL at Day 1 of admission

Range from 5.3–9.7 103/uL during hospital stay (4.0–11.0 103/uL)

 Hemoglobin

12.8 g/dL at Day 1 of admission

Range from 6.1–12.8 g/dL during hospital stay (12-16 g/dL)

 Platelet count

260 103/uL at Day 1 of admission

Range from 68.0–260 103/uL during stay (140–440 103/uL)

Chemistry

Aldolase

12.4 (< 8.2 U/L)

Creatine kinase

17 to 26 U/L during admission (25–140 U/L)

Alanine aminotransferase (ALT)

15 to 227 U/L during admission (7-35 U/L)

  Lactic Acid

2.1 mmol/L at day 1 of admission

Range from 0.9–4.1 mmol/L during admission stay

Infectious

 Culture, Blood

No growth

 Culture, Respiratory aspiration

No growth

 Culture, Fungal in respiratory aspiration

No growth

 Culture, Urine

No growth

 Cocci-Direct PCR

Negative

 Legionella Urine antigen

Negative

 Mycoplasma Pnuemoniae

Negative

 Strep Pneumoniae Urine antigen

Positive

 Upper respiratory viral panels

Negative

 Influenza A/B PCR

Negative

 HIV AB AG screen

Negative

Autoimmune

 Anti-neutrophil cytoplasmic antibody (ANCA)

Negative

 Antinuclear antibody reflex (ANA)

Positive, titer 1:160

 SS-A/Ro IgG antibody

1.2 positive (< 1.0 Negative)

 SS-B/La IgG antibody

< 1.0Negative (< 1.0 Negative)

 Anti-topoisomerase (SCL-70) IgG antibody

< 1.0 Negative (< 1.0 Negative)

 Centromere auto antibody

< 1.0 Negative (< 1.0 Negative)

 Double strand DNA (dsDNA)

1 IU/mL (< 5 IU/mL)

 Smith IgG

< 1.0 negative (< 1.0 Negative)

 Ribonucleic protein (U1 RNP/snRNP) IgG

< 1.0 negative (< 1.0 Negative)

 Myositis panel (collection date: Hospital Day 8)

Jo-1 Ab < 11 (< 11 SI)

PL-7 Ab 60 (< 11 SI)

PL-12 Ab < 11 (< 11 SI)

EJ Ab < 11 (< 11 SI)

OJ Ab < 11 (< 11 SI)

SRP Ab < 11 (< 11 SI

Mi-2 Alpha Ab < 11(< 11 SI)

Mi-2 Beta Ab < 11 (< 11 SI)

MDA-5 Ab 89 (< 11 SI)

TIF-1y Ab < 11 (< 11 SI)

NXP-2 Ab < 11 (< 11 SI)

 Myositis panel (collection date: Hospital Day 16)

Jo-1 Ab < 11 (< 11 SI)

PL-7 Ab61 (< 11 SI)

PL-12 Ab < 11 (< 11 SI)

EJ Ab < 11 (< 11 SI)

OJ Ab < 11 (< 11 SI)

SRP Ab < 11 (< 11 SI

Mi-2 Alpha Ab < 11(< 11 SI)

Mi-2 Beta Ab < 11 (< 11 SI)

MDA-5 Ab 78 (< 11 SI)

TIF-1y Ab < 11 (< 11 SI)

NXP-2 Ab < 11 (< 11 SI)

  1. Jo-1 (antihistidyl-tRNA synthetase), PL-7 (threonyl), PL-12 (alanyl), EJ (glycyl), OJ (isoleucyl), Mi-2 (Mi-2/nucleosome remodelling and deacetylase (NuRD), SRP (signal recognition particle), MDA5 (melanoma-differentiation associated gene 5), TIF-1 y (intermediary factor 1-gamma), NXP-2(nuclear matrix protein),