Table 2 Comparison on coexistent anti-aminoacyl-tRNA synthetase (anti-ARS)-interstitial lung disease (ILD) dermatomyositis with anti-melanoma differentiation-associated gene 5 (MDA5)-ILD dermatomyositis
Naniwa et al. [3] | Takecuchi et al. [4] | Current case | |
|---|---|---|---|
Patient ethnicity | Japanese | Japanese | Hispanic |
Gender | Male | Female | Female |
Age | 70-year-old | 53-year-old | 27-year-old |
Anti-ARS antibodies | Yes, anti-threonyl-transfer RNA synthetase (anti-PL-7) | Yes, Anti-glycyl-tRNA synthetase (anti-EJ) | Yes, anti-threonyl-transfer RNA synthetase (anti-PL-7) |
Anti-MDA-5 antibodies | Yes | Yes | Yes |
Diagnostic testing tool | Immunoprecipitation assay | Immunoprecipitation assay | Commercial Immunoblot assay |
Skin manifestation | Facial rash, a V-sign rash, a periungual erythema, and nail fold bleeding | heliotrope rash, facial erythema, Gottron papules with some shallow ulcers, mechanic’s hands and periungual erythema | forme fruste of Gottron’s patches |
Pulmonary Manifestation | Fine crackles were heard bilaterally in the lower lung field | Lung auscultation identified considerable fine crackles bilaterally | Diffuse crackles at lung auscultation bilaterally |
Chest computed tomography findings | Not done | Initial presentation with anti-EJ only: lower peripheral reticulation and ground-glass attenuation (GGA) 15 years after onset during exacerbation with anti-MDA5 only: rapidly progressive course with newly developed random GGA | Extensive ground glass opacities bilaterally without bronchiectasis |