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Table 2 Comparison on coexistent anti-aminoacyl-tRNA synthetase (anti-ARS)-interstitial lung disease (ILD) dermatomyositis with anti-melanoma differentiation-associated gene 5 (MDA5)-ILD dermatomyositis

From: Double anti-PL-7 and anti-MDA-5 positive Amyopathic Dermatomyositis with rapidly progressive interstitial lung disease in a Hispanic patient

  Naniwa et al. [3] Takecuchi et al. [4] Current case
Patient ethnicity Japanese Japanese Hispanic
Gender Male Female Female
Age 70-year-old 53-year-old 27-year-old
Anti-ARS antibodies Yes, anti-threonyl-transfer RNA synthetase (anti-PL-7) Yes, Anti-glycyl-tRNA synthetase (anti-EJ) Yes, anti-threonyl-transfer RNA synthetase (anti-PL-7)
Anti-MDA-5 antibodies Yes Yes Yes
Diagnostic testing tool Immunoprecipitation assay Immunoprecipitation assay Commercial Immunoblot assay
Skin manifestation Facial rash, a V-sign rash, a periungual erythema, and nail fold bleeding heliotrope rash, facial erythema, Gottron papules with some shallow ulcers, mechanic’s hands and periungual erythema forme fruste of Gottron’s patches
Pulmonary Manifestation Fine crackles were heard bilaterally in the lower lung field Lung auscultation identified considerable fine crackles bilaterally Diffuse crackles at lung auscultation bilaterally
Chest computed tomography findings Not done Initial presentation with anti-EJ only: lower peripheral reticulation and ground-glass attenuation (GGA)
15 years after onset during exacerbation with anti-MDA5 only:
rapidly progressive course with newly developed random GGA
Extensive ground glass opacities bilaterally without bronchiectasis