Variables | Total (n = 693) | IPA group (n = 21) | Control group (n = 672) | p-valuea |
---|---|---|---|---|
Age (years, median, IQR) | 61.0 (36.0–76.0) | 67.0 (61.0–82.0) | 60.0 (36.0–76.0) | <  0.001 |
Male (n, %) | 461 (66.5) | 18 (85.7) | 443 (65.9) | 0.058 |
BMI (kg/m2, mean ± SD) | 24.4 ± 3.6 | 21.5 ± 0.4 | 24.5 ± 3.6 | 0.014 |
Comorbidities (n, %) | 402 (58.0) | 18 (85.7) | 384 (57.1) | 0.009 |
 Diabetes mellitus | 92 (13.3) | 15 (71.4) | 77 (11.5) | <  0.001 |
 Cerebrovascular disease | 72 (10.4) | 4 (19.0) | 68 (10.1) | 0.338 |
 COPD | 40 (5.8) | 6 (28.6) | 34 (5.1) | <  0.001 |
 Asthma | 19 (2.7) | 3 (14.3) | 16 (2.4) | 0.009 |
 Chronic kidney disease | 16 (2.3) | 2 (9.5) | 14 (2.1) | 0.134 |
 Malignant solid tumor | 16 (2.3) | 0 (0.0) | 16 (2.4) | > 0.999 |
 Chronic congestive heart failure | 3 (0.4) | 3 (14.3) | 0 (0.0) | <  0.001 |
Smoking history (n, %) | 243 (35.1) | 7 (33.3) | 236 (35.1) | 0.866 |
Alcoholism history (n, %) | 92 (13.3) | 0 (0.0) | 92 (13.7) | 0.135 |
Antibiotics use before admission (n, %) | 587 (84.7) | 15 (71.4) | 572 (85.1) | 0.159 |
Clinical characteristics (n, %) | ||||
 Confusion | 32 (4.6) | 0 (0.0) | 32 (4.8) | 0.620 |
 SBP < 90 mmHg | 8 (1.2) | 1 (4.8) | 7 (1.0) | 0.593 |
 Leukocytes > 10 × 109/L | 118 (17.0) | 15 (71.4) | 103 (15.3) | <  0.001 |
 Lymphocytes < 0.8 × 109/L | 299/677 (44.2) | 15 (71.4) | 284/656 (43.3) | 0.011 |
 HB < 100 g/L | 69 (10.0) | 5 (23.8) | 64 (9.5) | 0.075 |
 Albumin < 35 g/L | 58/639 (9.1) | 6 (28.6) | 52/618 (8.4) | 0.006 |
 BG > 11 mmol/L | 48 (6.9) | 0 (0.0) | 48 (7.1) | 0.405 |
 BUN > 7 mmol/L | 183/685 (26.7) | 9 (42.9) | 174/664 (26.2) | 0.090 |
 Serum PCT > 0.1 ng/ml | 248/541 (45.8) | 2 (9.5) | 246/520 (47.3) | 0.001 |
 PO2/FiO2 < 300 mmHg | 340/639 (53.2) | 16 (76.2) | 324/618 (52.4) | 0.032 |
Radiology (n, %) | ||||
 Cavity | 19 (2.7) | 3 (14.3) | 16 (2.4) | 0.009 |
 Multiple nodules | 151 (21.8) | 8 (38.1) | 143 (21.3) | 0.116 |
ICs use before IPA diagnosis (n, %) | 3 (0.4) | 3 (14.3) | 0 (0.0) | <  0.001 |
Systemic corticosteroids use before IPA diagnosis (n, %) | 132 (19.0) | 18 (85.7) | 114 (17.0) | <  0.001 |
Dose of systemic corticosteroids a (mg/kg, mean ± SD) | 0.6 ± 0.3 | 0.6 ± 0.3 | 0.6 ± 0.3 | 0.853 |
Early NAIs b use (n, %) | 232 (33.3) | 10 (47.6) | 222 (33.0) | 0.163 |
Coinfection with other community-acquired pathogens (n, %) | 265 (38.2) | 3 (14.3) | 262 (39.0) | 0.016 |