Table 4 Cox proportional hazard analyses for factors affecting relapse free survival

Gender

female

1

male

1.92 (1.27–2.99)

< 0.01

Age

< 70y

1

≥ 70y

1.11 (0.75–1.63)

0.57

Charlson comorbidity index

0–2

1

3–4

1.29 (0.41–7.85)

0.70

Smoking status

never

1

Former / current

2.10 (1.38–3.28)

< 0.01

CEA

≤ 5 ng/ml

1

1

>  5 ng/ml

1.98 (1.36–2.89)

< 0.01

1.58 (1.05–2.38)

0.02

Operative approach

Thoracotomy

1

VATS

0.57 (0.33–0.82)

< 0.01

Wound length

≤ 10 cm

1

>  10 cm

2.07 (1.37–3.08)

< 0.01

Operation time

≤ 248 min

1

>  248 min

1.62 (1.09–2.44)

< 0.01

Operative procedure

Seg / Lob

1

Bilob / Pneumo

1.99 (1.01–3.55)

0.04

pStage

I

1

1

II - IIIA

4.59 (3.13–6.78)

< 0.01

2.57 (1.60–4.18)

<  0.01

Histology

Ad

1

Non-Ad

1.32 (0.86–1.97)

0.19

Differentiation

G1

1

G2 – G4

2.09 (1.38–3.24)

< 0.01

Ly

absent

1

present

4.38 (2.25–9.01)

< 0.01

V

absent

1

1

present

3.26 (2.16–5.05)

< 0.01

1.95 (1.15–3.38)

0.01

preCRP

≤ 0.14

1

1

>  0.14

2.80 (1.91–4.17)

<  0.01

1.91 (1.22–3.00)

< 0.01

postCRP

≤ 14.49

1

>  14.49

1.83 (1.24–2.72)

< 0.01

Clavien-Dindo grade

0 - I

1

II - IIIb

1.36 (0.86–2.09)

0.17