| |
Perioda,b
|
OSNRC
|
SNC
|
P-valuec
|
|---|
|
SpO2 (%)
|
1
|
− 1 (− 2 to − 0.75)
|
−1.5 (− 2.2 to − 1)
|
0.44
|
|
2
|
− 1.5 (− 2.8 to − 1)
|
0 (−1 to 1.2)
|
0.1
|
|
RR (min−1)
|
1
|
−2 (− 6 to − 1)
|
0 (− 7 to 2)
|
0.7
|
|
2
|
2 (2 to 4)
|
−3 (− 5 to 0.5)
|
0.1
|
|
HR (min−1)
|
1
|
−14 (− 16 to − 11)
|
1 (− 0.25 to 3.5)
|
0.0086
|
|
2
|
3 (−5.2 to 6)
|
−4 (− 9.8 to 2.8)
|
0.48
|
|
pCO2 (mm Hg)
|
1
|
7.5 (5.2 to 7.9)
|
7.6 (5 to 9.2)
|
0.79
|
|
2
|
2.2 (1.1 to 3.7)
|
0.5 (−1.7 to 1.3)
|
0.11
|
|
pH
|
1
|
− 0.063 (− 0.073 to − 0.041)
|
− 0.073 (− 0.11 to − 0.035)
|
0.44
|
|
2
|
− 0.01 (− 0.018 to − 0.0065)
|
0.0025 (− 0.0092 to 0.0083)
|
0.34
|
|
Lactate (mmol/L)
|
1
|
− 0.48 (− 0.72 to − 0.32)
|
0.33 (− 0.4 to 0.98)
|
0.028
|
|
2
|
−0.13 (− 0.15 to 0.13)
|
0.3 (0.1 to 0.43)
|
0.18
|
|
Base excess (mmol/L)
|
1
|
0.5 (0 to 2.2)
|
0 (0 to 0.25)
|
0.34
|
|
2
|
0.5 (0 to 1)
|
−1 (− 1.2 to 0.25)
|
0.099
|
- Data represent the median (interquartile range)
- aDuring Period 1, patients were treated with OSNRC (Group A, n = 8) or SNC (Group B, n = 8) for 1 hour
- bDuring Period 2, patients were treated with OSNRC (Group B, n = 6) or SNC (Group A, n = 8) for 1 hour
- cRepresents p-value for difference between OSNRC and SNC treatments
