Fig. 6

miR-133a/HOXB13 pathway involved in the lncRNA SNHG14 regulation of A549/DDP cell sensitivity to DDP. a and b A549/DDP cells under DDP treatment (1 μg/ml) were co-transfected with sh-SNHG14 and miR-133a inhibitor, then the cell viability and proliferation was determined by CCK-8 and colony formation experiments. c and d Flow cytometry was adopted to analyze the effects of co-transfection of sh-SNHG14 and miR-133a inhibitor on the cell cycle and apoptosis of A549/DDP cell in the presence of DDP (1 μg/ml). e Western blot was utilized to test the protein levels of Bcl-2, Bax, cleaved-caspase-3 and HOXB13 in A549/DDP cells co-transfected with sh-SNHG14 and miR-133a inhibitor under DDP treatment (1 μg/ml)