Table 1 The summary of included studies
From: The meta-analysis for ideal cytokines to distinguish the latent and active TB infection
Cytokines | Author (year) | Country (incidence) | Subjects (ATB/LTBI: n) | Detection methods | HIV status | Stimulator with Mtb antigens | TP (n) | FP (n) | FN (n) | TN (n) |
|---|---|---|---|---|---|---|---|---|---|---|
IL-2 | Suzukawa, M 2016 [38] | Japan (low) | Adults (31/29) | Luminex | negative | Mtb-specific antigens | 30 | 22 | 1 | 7 |
Wu, J 2016 [39] | China (high) | Adults (25/36) | Luminex | NA | PPD | 21 | 15 | 4 | 21 | |
Kamakia, R 2017 [29] | Kenya (high) | Adults (19/16) | Luminex | NA | Mtb-specific antigens | 14 | 1 | 5 | 15 | |
Movahedi, B 2017 [33] | Iranian (high) | Adults (33/33) | ELISPOT | negative | Mtb-specific antigens | 23 | 19 | 10 | 14 | |
Movahedi, B 2017 [33] | Iranian (high) | Adults (33/33) | ELISPOT | negative | AlaDH | 25 | 7 | 8 | 26 | |
Biselli, R 2010 [31] | Italy (low) | Adults (20/20) | ELISA | negative | Mtb-specific antigens | 18 | 1 | 2 | 19 | |
Chiappini, E 2012 [32] | Italy (low) | Children (25/21) | ELISPOT | NA | AlaDH | 25 | 4 | 0 | 17 | |
Della Bella, C 2018 [34] | Italy (low) | Adults (73/88) | ELISPOT | NA | ESAT-6 | 63 | 56 | 10 | 32 | |
Della Bella, C 2018 [34] | Italy (low) | Adults (73/88) | ELISPOT | NA | CFP-10 | 59 | 40 | 14 | 48 | |
Della Bella, C 2018 [34] | Italy (low) | Adults (73/88) | ELISPOT | NA | Ala-DH | 70 | 0 | 3 | 88 | |
Kim, S 2015 [40] | Korea (low) | Adults (28/22) | RT-PCR | negative | Mtb-specific antigens | 27 | 19 | 1 | 3 | |
IP-10 | Suzukawa, M 2016 [38] | Japan (low) | Adults (31/29) | Luminex | negative | Mtb-specific antigens | 23 | 14 | 8 | 15 |
Wu, J 2016 [39] | China (high) | Adults (25/36) | Luminex | NA | PPD | 19 | 12 | 6 | 24 | |
Jeong, Y. H 2014 [28] | Korea (low) | Adults (33/20) | Luminex | NA | Mtb-specific antigens | 23 | 0 | 10 | 20 | |
Jeong, Y. H 2014 [28] | Korea (low) | Adults (33/20) | Luminex | NA | Mtb-specific antigens | 31 | 2 | 2 | 18 | |
Petrone, L 2018 [35] | Italy (low) | Adults (36/31) | ELISA | negative | Mtb-specific antigens | 21 | 12 | 15 | 19 | |
Wergeland, I 2015 [36] | Norway (low) | Adults (65/34) | Luminex | positive | Mtb-specific antigens | 65 | 0 | 0 | 34 | |
Wergeland, I 2015 [36] | Norway (low) | Adults (65/34) | Luminex | negative | Mtb-specific antigens | 46 | 6 | 19 | 28 | |
Amanatidou, V 2012 [30] | Athens (low) | Children (54/53) | ELISA | negative | Mtb-specific antigens | 45 | 11 | 9 | 42 | |
Nonghanphithak, D 2017 [37] | Thailand (high) | Adults (48/38) | ELISA | negative | Mtb-specific antigens | 20 | 11 | 28 | 27 | |
Kim, S 2015 [40] | Korea (low) | Adults (28/22) | RT-PCR | negative | Mtb-specific antigens | 28 | 18 | 0 | 4 | |
IL-5 | Suzukawa, M 2016 [38] | Japan (low) | Adults (31/29) | Luminex | negative | Mtb-specific antigens | 27 | 14 | 4 | 15 |
Kamakia, R 2017 [29] | Kenya (high) | Adults (19/16) | Luminex | negative | Mtb-specific antigens | 14 | 1 | 5 | 15 | |
Won, E. J 2016 [16] | Korea (low) | Adults(36/15) | Luminex | negative | Mtb-specific antigens | 14 | 0 | 22 | 15 | |
IL-13 | Suzukawa, M 2016 [38] | Japan (low) | Adults (31/29) | Luminex | negative | Mtb-specific antigens | 17 | 13 | 14 | 16 |
Jeong, Y. H 2014 [28] | Korea (low) | Adults (33/20) | Luminex | NA | Mtb-specific antigens | 33 | 8 | 0 | 12 | |
Jeong, Y. H 2014 [28] | Korea (low) | Adults (33/20) | Luminex | NA | Mtb-specific antigens | 26 | 3 | 7 | 17 | |
Kamakia, R 2017 [29] | Kenya (high) | Adults (19/16) | Luminex | negative | Mtb-specific antigens | 11 | 1 | 8 | 15 | |
IFN-γ | Suzukawa, M 2016 [38] | Japan (low) | Adults (31/29) | ELISA | negative | Mtb-specific antigens | 28 | 12 | 3 | 17 |
Wu, J 2016 [39] | China (high) | Adults (25/36) | ELISPOT | NA | Mtb-specific antigens | 13 | 4 | 12 | 23 | |
Jeong, Y. H 2014 [28] | Korea (low) | Adults (33/20) | ELISA | NA | Mtb-specific antigens | 31 | 8 | 2 | 12 | |
Jeong, Y. H 2014 [28] | Korea (low) | Adults (33/20) | ELISA | NA | Mtb-specific antigens | 29 | 5 | 4 | 15 | |
Kamakia, R 2017 [29] | Kenya (high) | Adults (19/16) | ELISA | NA | Mtb-specific antigens | 10 | 1 | 9 | 15 | |
Movahedi, B 2017 [33] | Iranian (high) | Adults (33/33) | ELISPOT | negative | Mtb-specific antigens | 11 | 5 | 22 | 28 | |
Movahedi, B 2017 [33] | Iranian (high) | Adults (33/33) | ELISPOT | negative | AlaDH | 16 | 12 | 17 | 21 | |
Kim, S 2015 [40] | Korea (low) | Adults (28/22) | RT-PCR | negative | Mtb-specific antigens | 20 | 6 | 8 | 16 | |
IL-10 | Suzukawa, M 2016 [38] | Japan (low) | Adults (31/29) | Luminex | negative | Mtb-specific antigens | 20 | 3 | 11 | 26 |
Wu, J 2016 [39] | China (high) | Adults (25/36) | Luminex | NA | PPD | 20 | 15 | 5 | 21 | |
Won, E. J 2016 [16] | Korea (low) | Adults(36/15) | Luminex | negative | Mtb-specific antigens | 23 | 3 | 13 | 12 | |
TNF-α | Wu, J 2016 [39] | China (high) | Adults (25/36) | Luminex | NA | PPD | 20 | 17 | 5 | 19 |
Suzukawa, M 2016 [38] | Japan (low) | Adults (31/29) | Luminex | negative | Mtb-specific antigens | 9 | 2 | 22 | 27 | |
Kim, S 2015 [40] | Korea (low) | Adults (28/22) | RT-PCR | negative | Mtb-specific antigens | 27 | 12 | 1 | 10 |