Table 2 – Cox proportional hazard regression analysis for all-cause mortality and disease progression. Disease progression was defined as death or absolute forced vital capacity (FVC) decline ≥10%. *Values of HR were adjusted for GAP (Gender, Age, Physiology) stage index. **within LNE+ patients

LNE + (vs LNE -)

2.65 (1.09–6.46)

0.032

2.39 (0.96–5.95)

0.062

1.75 (0.9–3.39)

0.097

1.87 (0.93–3.76)

0.078

 1

1.49 (0.42–5.3)

0.538

1.1 (0.27–4.5)

0.894

1.43 (0.54–3.83)

0.472

1.65 (0.61–4.47)

0.326

 2

1.62 (0.54–4.84)

0.386

1.55 (0.52–4.66)

0.436

1.41 (0.63–3.17)

0.405

1.53 (0.67–3.52)

0.313

  ≥ 3

5.72 (2.18–14.98)

< 0.001

5.03 (1.86–13.62)

0.001

2.67 (1.19–5.97)

0.017

2.99 (1.22–7.33)

0.017

 Larger LNE**(mm)

1.17 (1.04–1.32)

0.01

1.14 (0.99–1.29)

0.058

1.05 (0.89–1.23)

0.57

0.93 (0.84–1.18)

0.928