Table 1 Characteristics of patients with organizing pneumonia associated with Mycobacterium tuberculosis infection
| Â | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 |
|---|---|---|---|---|---|---|
Sex/age | M/81 | M/71 | F/53 | M/57 | M/78 | M/70 |
Symptom | General weakness, Fever | Chronic cough | Fever | Dyspnea | Mental status change | Asymptomatic |
Past history | Hypertension | Neurofibromatosis, GIST, old pulmonary tuberculosis | Diabetes, Hyperlipidemia | (−) | Spinal disease | (−) |
Previous medication | Losartan | Cilostazol, choline alfoscerate, nebivolol, olmesartan, pantoprazole, udenafil | Metformin, sitagliptin, rosuvastatin, tibolone, valsartan, pioglitazone, glimepiride | (−) | Naproxen, eperisone, mecobalamin, gabapentin, limaprost, esomeprazole | (−) |
Smoking | (−) | (−) | (+) 10pack-years | (+) 20pack-years | (−) Ex-smoker. 25pack-years | (−) Ex-smoker, 10pack-years |
Chest CT | Bilateral consolidation | Consolidation in LLL | Consolidation in RUL | Bilateral consolidation | Bilateral consolidation | Nodule |
Sputum | ||||||
 AFB smear | (−) | (−) | (−) | (−) | (−) | (−) |
Bronchial washing or BAL fluid | ||||||
 AFB smear | (+) | (−) | (−) | (−) | (−) | (−) |
 MTB PCR | (+) | (+) | (+) | (+) | (+) | (+) |
 AFB Culture | (+) | (+) | (+) | (+) | (+) | (+) |
Biopsy | OP with a few of small granuloma | OP | OP | OP | OP | OP |
Tissue AFB smear | (−) | N/A | N/A | N/A | N/A | N/A |
BAL | (−) | (+) cell count 550/μL, neutrophil 61%, lymphocyte 11% | (−) | (+) cell count 150/μL, neutrophil 3%, lymphocyte 45% | (+) cell count 450/μL, neutrophil 6%, lymphocyte 29% | (−) |
Ventilator Tx | (−) | (−) | (−) | (+) | (−) | (−) |
DST | All sensitive | All sensitive | All sensitive | All sensitive | All sensitive | All sensitive |
Antituberculosis drugs | Isoniazid, rifampin, ethambutol, pyrazinamide, for 6 months | Isoniazid, rifampin, ethambutol, pyrazinamide for 6 months | Isoniazid, rifampin, ethambutol, pyrazinamide for 6 months | Isoniazid, rifampin, ethambutol, pyrazinamide ➔ isoniazid, pyrazinamide, levofloxacin for 18 months | Isoniazid, rifampin, ethambutol, pyrazinamide for 2 months ➔ quit the medicine by himself | Isoniazid, rifampin, ethambutol, pyrazinamide for 6 months |
Treatment of steroid | (−) | (+) | (−) | (+) | (−) | (−) |
Resolution | (+) | (+) | (+) | (+) | (+) | (+) |
Recur | (−) | (−) | (−) | (−) | (−) | (−) |
Mortality | Alive | Alive | Alive | Alive | Alive | Alive |