Table 3 Biomarker levels in the control group (conventional treatment) and in the intervention group (duration of antibiotic treatment based on IDSA / ATS), in the per-protocol analysis
Control n = 61 | Intervention n = 75 | p value | |
|---|---|---|---|
ProADM day 1 | 1.01 (0.78, 1.32) | 0.91 (0.68, 1.25) | 0.41 |
ProADM day 5 | 0.81 (0.57, 1.01) | 0.81 (0.54, 1.19) | 0.59 |
ProADM day 30 | 0.70 (0.49, 1.01) | 0.68 (0.49, 0.93) | 0.93 |
ProADM difference from day 5 to day 30 | −0.07 (−0.23, 0.01) | −0.09 (−0.15, 0.03) | 0.65 |
PCR day 1 | 240.20 (86.80, 301.30) | 159.75 (87.75, 302.60) | 0.47 |
PCR day 5 | 47.50 (25.10, 88.50) | 37.10 (15.70, 79.30) | 0.20 |
PCR day 30 | 2.55 (1.60, 7.80) | 2.50 (1.30, 5.40) | 0.48 |
PCR difference from day 5 to day 30 | −42.30 (−86.70, −21.90) | −32.45 (−73.35, −14.50) | 0.17 |
PCT day 1 | 0.67 (0.18, 3.34) | 0.49 (0.15, 1.68) | 0.67 |
PCT day 5 | 0.19 (0.09, 0.50) | 0.17 (0.06, 0.75) | 0.87 |
PCT day 30 | 0.04 (0.02, 0.06) | 0.04 (0.03, 0.06) | 0.54 |
PCT difference from day 5 to day 30 | −0.12 (−0.40, −0.04) | −0.18 (− 0.69, − 0.03) | 0.49 |