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Table 1 Integrative genomics analysis highlighted 11 highlighted genes contributed to moderate-to-severe asthma risk

From: Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets

Gene name Simulated P-value (Sherlock analysis of Dataset #3) Simulated P-value (Sherlock analysis of Dataset #4) Simulated P-value (Sherlock analysis of Dataset #5) MAGMA-based P-value
(Dataset #1)
MAGMA-based P value (Dataset #2, negative control) GWAS Catalog documented genes
HLA-DRB5 7.93 × 10−7 1.60 × 10−3 4.09 × 10−6 7.57 × 10−10 0.11 Documented gene
HLA-DRB1 7.93 × 10−7 4.64 × 10−6 4.09 × 10− 6 1.41 × 10−11 0.59 Documented gene
GNGT2 1.11 × 10−5 2.30 × 10−4 1.83 × 10−2 1.42 × 10− 2 0.48 Documented gene
HLA-DQA1 2.85 × 10−5 7.73 × 10−7 1.49 × 10−3 2.90 × 10−23 0.58 Documented gene
SLC22A5 1.85 × 10−4 3.87 × 10−5 2.66 × 10− 5 1.23 × 10−6 0.46 Documented gene
STAT6 2.19 × 10−4 2.75 × 10−2 3.31 × 10− 2 1.94 × 10−11 0.97 Documented gene
MPI 1.90 × 10−3 2.02 × 10−2 2.39 × 10−2 1.12 × 10−5 0.84 Not documented gene
TLR6 3.63 × 10−3 3.54 × 10− 3 6.69 × 10− 3 4.10 × 10−2 0.93 Documented gene
DECR2 1.62 × 10−2 4.32 × 10− 2 1.58 × 10−4 2.22 × 10− 2 0.78 Not documented gene
LNPEP 2.28 × 10−2 5.55 × 10−4 4.33 × 10−2 3.98 × 10− 2 0.46 Not documented gene
TTC19 2.52 × 10−2 1.81 × 10−2 2.20 × 10− 2 3.23 × 10− 2 0.30 Not documented gene