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Table 1 Integrative genomics analysis highlighted 11 highlighted genes contributed to moderate-to-severe asthma risk

From: Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets

Gene name

Simulated P-value (Sherlock analysis of Dataset #3)

Simulated P-value (Sherlock analysis of Dataset #4)

Simulated P-value (Sherlock analysis of Dataset #5)

MAGMA-based P-value

(Dataset #1)

MAGMA-based P value (Dataset #2, negative control)

GWAS Catalog documented genes

HLA-DRB5

7.93 × 10−7

1.60 × 10−3

4.09 × 10−6

7.57 × 10−10

0.11

Documented gene

HLA-DRB1

7.93 × 10−7

4.64 × 10−6

4.09 × 10− 6

1.41 × 10−11

0.59

Documented gene

GNGT2

1.11 × 10−5

2.30 × 10−4

1.83 × 10−2

1.42 × 10− 2

0.48

Documented gene

HLA-DQA1

2.85 × 10−5

7.73 × 10−7

1.49 × 10−3

2.90 × 10−23

0.58

Documented gene

SLC22A5

1.85 × 10−4

3.87 × 10−5

2.66 × 10− 5

1.23 × 10−6

0.46

Documented gene

STAT6

2.19 × 10−4

2.75 × 10−2

3.31 × 10− 2

1.94 × 10−11

0.97

Documented gene

MPI

1.90 × 10−3

2.02 × 10−2

2.39 × 10−2

1.12 × 10−5

0.84

Not documented gene

TLR6

3.63 × 10−3

3.54 × 10− 3

6.69 × 10− 3

4.10 × 10−2

0.93

Documented gene

DECR2

1.62 × 10−2

4.32 × 10− 2

1.58 × 10−4

2.22 × 10− 2

0.78

Not documented gene

LNPEP

2.28 × 10−2

5.55 × 10−4

4.33 × 10−2

3.98 × 10− 2

0.46

Not documented gene

TTC19

2.52 × 10−2

1.81 × 10−2

2.20 × 10− 2

3.23 × 10− 2

0.30

Not documented gene