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Table 2 NTM disease and Comorbidity complexes

From: Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: a claims-data analysis

Comorbidity complexes NTM(N = 419)
n (%)
non-NTM (N = 4190)
n (%)
Odds ratio [95% CI] P value
Arrhythmia 28 (6.68) 176 (4.20) 1.63 [1.04–2.48] 0.0243
Aspergillosis 8 (1.90) 0 (0) +∞ [17.3 − +∞] < 0.0001*
Asthma 77 (18.3) 194 (4.63) 4.63 [3.43–6.21] < 0.0001*
Bone fracture 13 (3.10) 64 (1.52) 2.06 [1.03–3.83] 0.0255
Breast cancer 4 (0.954) 43 (1.02) 0.93 [0.24–2.58] > 0.99
Chronic heart failure 31 (7.39) 130 (3.10) 2.49 [1.61–3.77] < 0.0001*
Chronic kidney disease 16 (3.81) 54 (1.28) 3.04 [1.61–5.45] 0.000403*
COPD 13 (3.10) 22 (0.525) 6.06 [2.78–12.69] < 0.0001*
Crohn’s disease 2 (0.477) 0 (0) +∞ [1.88 − +∞] 0.00825
Depression 16 (3.81) 107 (2.55) 1.51 [0.83–2.61] 0.149
Diabetes mellitus 62 (14.7) 608 (14.5) 1.02 [0.76–1.36] 0.884
Diffuse panbronchiolitis 7 (1.67) 0 (0) +∞ [14.57 − +∞] < 0.0001*
Dyslipidemia 105 (25.0) 1110 (26.4) 0.93 [0.73–1.17] 0.561
GERD 83 (19.8) 355 (8.47) 2.67 [2.02–3.49] < 0.0001*
Heart valve disease 11 (2.62) 54 (1.28) 2.06 [0.97–4.03] 0.0455
HIV infection 0 (0) 0 (0) NA NA
Hypertension 110 (26.2) 1166 (27.8) 0.92 [0.73–1.16] 0.529
Ischemic heart disease 29 (6.92) 191 (4.55) 1.56 [1.00–2.35] 0.04
Interstitial pneumonia 25 (5.96) 14 (0.334) 18.89 [9.36–39.70] < 0.0001*
Liver cirrhosis 4 (0.954) 25 (0.596) 1.61 [0.40–4.68] 0.33
Lung cancer 19 (4.53) 13 (0.310) 15.24 [7.08–33.86] < 0.0001*
Osteoporosis 46 (10.9) 220 (5.25) 2.23 [1.56–3.13] < 0.0001*
Other cancer 41 (9.78) 117 (2.79) 3.77 [2.54–5.52] < 0.0001*
Ovary cancer 1 (0.238) 8 (0.190) 1.25 [0.028–9.37] 0.576
PM/DM 1 (0.238) 2 (0.0477) 5.01 [0.085–96.47] 0.249
Prostate cancer 0 (0) 15 (0.357) 0 [0–2.79] 0.389
Rheumatoid arthritis 23 (5.48) 66 (1.57) 3.63 [2.13–5.99] < 0.0001*
Sjögren syndrome 10 (2.38) 13 (0.310) 7.85 [3.06–19.50] < 0.0001*
SLE 3 (0.715) 7 (0.167) 4.31 [0.72–18.95] 0.0552
Systemic sclerosis 4 (0.954) 3 (0.0715) 13.44 [2.26–91.95] 0.00189
  1. COPD Chronic obstructive pulmonary diseases, GERD Gastroesophageal reflux, HIV Human immunodeficiency virus, PM/DM Polymyositis/dermatomyositis, SLE Systemic lupus erythematosus, *statistically different, NA Not applicable