Table 3 NTM disease and Comorbidity complexes analyzed separating sexes
Male N = 1474 | Female N = 3135 | |||||||
|---|---|---|---|---|---|---|---|---|
Comorbidity complexes | NTM, N = 134 | non-NTM, N = 1340 | Odds ratio [95% CI] | P value | NTM, N = 285 | non-NTM, N = 2850 | Odds ratio [95% CI] | P value |
Arrhythmia | 15 (11.19) | 71 (5.29) | 2.25 [1.16–4.12] | 0.0105 | 13 (4.56) | 105 (3.68) | 1.25 [0.64–2.27] | 0.417 |
Aspergillosis | 5 (3.73) | 0 (0) | +∞ [9.36 − +∞] | < 0.0001* | 3 (1.05) | 0 (0) | +∞ [4.15 − +∞] | 0.000744* |
Asthma | 30 (22.3) | 60 (4.47) | 6.14 [3.65–10.17] | < 0.0001* | 47 (16.4) | 134 (4.70) | 4.00 [2.73–5.78] | < 0.0001* |
Bone fracture | 3 (2.23) | 8 (0.597) | 3.81 [0.64–16.11] | 0.0705 | 10 (3.50) | 56 (1.96) | 1.81 [0.82–3.64] | 0.0854 |
Breast cancer | 0 (0) | 1 (0.0746) | 0 [0–387.6] | > 0.99 | 4 (1.40) | 42 (1.47) | 0.95 [0.25–2.65] | > 0.99 |
Chronic heart failure | 11 (8.20) | 43 (3.20) | 2.69 [1.22–5.49] | 0.00731 | 20 (7.01) | 87 (3.05) | 2.40 [1.37–4.01] | 0.00158 |
Chronic kidney disease | 5 (3.73) | 25 (1.86) | 2.04 [0.60–5.54] | 0.185 | 11 (3.85) | 29 (1.01) | 3.90 [1.74–8.16] | 0.000605* |
COPD | 9 (6.71) | 11 (0.820) | 8.67 [3.11–23.51] | < 0.0001* | 4 (1.40) | 11 (0.385) | 3.67 [0.85–12.49] | 0.0408 |
Crohn’s disease | 2 (1.49) | 0 (0) | +∞ [1.89 − +∞] | 0.0821 | 0 (0) | 0 (0) | NA | NA |
Depression | 2 (1.49) | 32 (2.38) | 0.62 [0.071–2.48] | 0.763 | 14 (4.91) | 75 (2.63) | 1.91 [0.98–3.47] | 0.0374 |
Diabetes mellitus | 28 (20.89) | 241 (17.98) | 1.20 [0.75–1.89] | 0.412 | 34 (11.9) | 367 (12.8) | 0.92 [0.61–1.34] | 0.71 |
Diffuse panbronchiolitis | 4 (2.98) | 0 (0) | +∞ [6.70 − +∞] | < 0.0001* | 3 (1.05) | 0 (0) | +∞ [4.15 − +∞] | 0.000744* |
Dyslipidemia | 26 (19.4) | 345 (25.7) | 0.69 [0.43–1.10] | 0.118 | 79 (27.7) | 765 (26.8) | 1.05 [0.79–1.38] | 0.779 |
GERD | 35 (26.1) | 118 (8.80) | 3.66 [2.31–5.71] | < 0.0001* | 48 (16.8) | 237 (8.31) | 2.23 [1.56–3.15] | < 0.0001* |
Heart valve disease | 6 (4.47) | 17 (1.26) | 3.64 [1.16–9.90] | 0.0139 | 5 (1.75) | 37 (1.29) | 1.36 [0.41–3.50] | 0.427 |
HIV infection | 0 (0) | 0 (0) | NA | NA | 0 (0) | 0 (0) | NA | NA |
Hypertension | 40 (29.8) | 432 (32.2) | 0.89 [0.59–1.33] | 0.628 | 70 (24.5) | 734 (25.7) | 0.94 [0.70–1.25] | 0.722 |
Ischemic heart disease | 14 (10.4) | 75 (5.59) | 1.97 [1.00–3.64] | 0.0344 | 15 (5.26) | 116 (4.07) | 1.31 [0.70–2.29] | 0.35 |
Interstitial pneumonia | 12 (8.95) | 4 (0.298) | 32.66 [9.71–141.0] | < 0.0001* | 13 (4.56) | 10 (0.350) | 13.55 [5.43–34.89] | < 0.0001* |
Liver cirrhosis | 3 (2.23) | 3 (0.223) | 10.17 [1.35–76.71] | 0.012 | 1 (0.350) | 22 (0.771) | 0.45 [0.011–2.82] | 0.716 |
Lung cancer | 10 (7.46) | 8 (0.597) | 13.37 [4.66–39.77] | < 0.0001* | 9 (3.15) | 5 (0.175) | 18.52 [5.53–70.69] | < 0.0001* |
Osteoporosis | 4 (2.98) | 10 (7.46) | 4.09 [0.92–14.42] | 0.0318 | 42 (14.7) | 210 (7.36) | 2.17 [1.48–3.13] | < 0.0001* |
Other cancer | 18 (13.4) | 45 (3.35) | 4.46 [2.35–8.16] | < 0.0001* | 23 (8.07) | 72 (2.52) | 3.39 [1.98–5.59] | < 0.0001* |
Ovary cancer | 0 (0) | 0 (0) | NA | NA | 1 (0.35) | 8 (0.280) | 1.25 [0.028–9.39] | 0.576 |
PM/DM | 0 (0) | 0 (0) | NA | NA | 1 (0.35) | 2 (0.0701) | 5.01 [0.085–96.61] | 0.249 |
Prostate cancer | 0 (0) | 15 (1.11) | 0 [0–2.79] | 0.387 | 0 (0) | 0 (0) | NA | NA |
Rheumatoid arthritis | 6 (4.47) | 5 (0.373) | 12.47 [3.12–52.32] | 0.00016* | 17 (5.96) | 61 (2.14) | 2.90 [1.56–5.12] | 0.000458* |
Sjögren syndrome | 0 (0) | 0 (0) | NA | NA | 10 (3.50) | 13 (0.456) | 7.92 [3.08–19.76] | < 0.0001* |
SLE | 0 (0) | 1 (0.0746) | 0 [0–387.6] | > 0.99 | 3 (1.05) | 6 (0.210) | 5.04 [0.81–23.74] | 0.0413 |
Systemic sclerosis | 1 (0.746) | 1 (0.0746) | 10.03 [0.13–785.3] | 0.174 | 3 (1.05) | 2 (0.0701) | 15.11 [1.72–181.5] | 0.0647 |