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Table 3 NTM disease and Comorbidity complexes analyzed separating sexes

From: Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: a claims-data analysis

  Male N = 1474 Female N = 3135
Comorbidity complexes NTM, N = 134 non-NTM, N = 1340 Odds ratio [95% CI] P value NTM, N = 285 non-NTM, N = 2850 Odds ratio [95% CI] P value
Arrhythmia 15 (11.19) 71 (5.29) 2.25 [1.16–4.12] 0.0105 13 (4.56) 105 (3.68) 1.25 [0.64–2.27] 0.417
Aspergillosis 5 (3.73) 0 (0) +∞ [9.36 − +∞] < 0.0001* 3 (1.05) 0 (0) +∞ [4.15 − +∞] 0.000744*
Asthma 30 (22.3) 60 (4.47) 6.14 [3.65–10.17] < 0.0001* 47 (16.4) 134 (4.70) 4.00 [2.73–5.78] < 0.0001*
Bone fracture 3 (2.23) 8 (0.597) 3.81 [0.64–16.11] 0.0705 10 (3.50) 56 (1.96) 1.81 [0.82–3.64] 0.0854
Breast cancer 0 (0) 1 (0.0746) 0 [0–387.6] > 0.99 4 (1.40) 42 (1.47) 0.95 [0.25–2.65] > 0.99
Chronic heart failure 11 (8.20) 43 (3.20) 2.69 [1.22–5.49] 0.00731 20 (7.01) 87 (3.05) 2.40 [1.37–4.01] 0.00158
Chronic kidney disease 5 (3.73) 25 (1.86) 2.04 [0.60–5.54] 0.185 11 (3.85) 29 (1.01) 3.90 [1.74–8.16] 0.000605*
COPD 9 (6.71) 11 (0.820) 8.67 [3.11–23.51] < 0.0001* 4 (1.40) 11 (0.385) 3.67 [0.85–12.49] 0.0408
Crohn’s disease 2 (1.49) 0 (0) +∞ [1.89 − +∞] 0.0821 0 (0) 0 (0) NA NA
Depression 2 (1.49) 32 (2.38) 0.62 [0.071–2.48] 0.763 14 (4.91) 75 (2.63) 1.91 [0.98–3.47] 0.0374
Diabetes mellitus 28 (20.89) 241 (17.98) 1.20 [0.75–1.89] 0.412 34 (11.9) 367 (12.8) 0.92 [0.61–1.34] 0.71
Diffuse panbronchiolitis 4 (2.98) 0 (0) +∞ [6.70 − +∞] < 0.0001* 3 (1.05) 0 (0) +∞ [4.15 − +∞] 0.000744*
Dyslipidemia 26 (19.4) 345 (25.7) 0.69 [0.43–1.10] 0.118 79 (27.7) 765 (26.8) 1.05 [0.79–1.38] 0.779
GERD 35 (26.1) 118 (8.80) 3.66 [2.31–5.71] < 0.0001* 48 (16.8) 237 (8.31) 2.23 [1.56–3.15] < 0.0001*
Heart valve disease 6 (4.47) 17 (1.26) 3.64 [1.16–9.90] 0.0139 5 (1.75) 37 (1.29) 1.36 [0.41–3.50] 0.427
HIV infection 0 (0) 0 (0) NA NA 0 (0) 0 (0) NA NA
Hypertension 40 (29.8) 432 (32.2) 0.89 [0.59–1.33] 0.628 70 (24.5) 734 (25.7) 0.94 [0.70–1.25] 0.722
Ischemic heart disease 14 (10.4) 75 (5.59) 1.97 [1.00–3.64] 0.0344 15 (5.26) 116 (4.07) 1.31 [0.70–2.29] 0.35
Interstitial pneumonia 12 (8.95) 4 (0.298) 32.66 [9.71–141.0] < 0.0001* 13 (4.56) 10 (0.350) 13.55 [5.43–34.89] < 0.0001*
Liver cirrhosis 3 (2.23) 3 (0.223) 10.17 [1.35–76.71] 0.012 1 (0.350) 22 (0.771) 0.45 [0.011–2.82] 0.716
Lung cancer 10 (7.46) 8 (0.597) 13.37 [4.66–39.77] < 0.0001* 9 (3.15) 5 (0.175) 18.52 [5.53–70.69] < 0.0001*
Osteoporosis 4 (2.98) 10 (7.46) 4.09 [0.92–14.42] 0.0318 42 (14.7) 210 (7.36) 2.17 [1.48–3.13] < 0.0001*
Other cancer 18 (13.4) 45 (3.35) 4.46 [2.35–8.16] < 0.0001* 23 (8.07) 72 (2.52) 3.39 [1.98–5.59] < 0.0001*
Ovary cancer 0 (0) 0 (0) NA NA 1 (0.35) 8 (0.280) 1.25 [0.028–9.39] 0.576
PM/DM 0 (0) 0 (0) NA NA 1 (0.35) 2 (0.0701) 5.01 [0.085–96.61] 0.249
Prostate cancer 0 (0) 15 (1.11) 0 [0–2.79] 0.387 0 (0) 0 (0) NA NA
Rheumatoid arthritis 6 (4.47) 5 (0.373) 12.47 [3.12–52.32] 0.00016* 17 (5.96) 61 (2.14) 2.90 [1.56–5.12] 0.000458*
Sjögren syndrome 0 (0) 0 (0) NA NA 10 (3.50) 13 (0.456) 7.92 [3.08–19.76] < 0.0001*
SLE 0 (0) 1 (0.0746) 0 [0–387.6] > 0.99 3 (1.05) 6 (0.210) 5.04 [0.81–23.74] 0.0413
Systemic sclerosis 1 (0.746) 1 (0.0746) 10.03 [0.13–785.3] 0.174 3 (1.05) 2 (0.0701) 15.11 [1.72–181.5] 0.0647
  1. COPD Chronic obstructive pulmonary diseases, GERD Gastroesophageal reflux, HIV Human immunodeficiency virus, PM/DM Polymyositis/dermatomyositis, SLE Systemic lupus erythematosus, *statistically different, NA Not applicable