Fig. 1

Experimental timeline of the study design. Mice were weighed and grouped at day − 6. Subsequently, the mice were orally pretreated with ASA (aspirin, 200 mg/kg/day), ATR (atorvastatin, 10 mg/kg/day), or an equal volume of 0.5% CMC-Na once daily (q.d.) for 7 days until day 0. On day 0, the mice were weighed and given with ASA, ATR, or 0.5% CMC-Na via the intragastric route 1 h prior to the induction of acute lung inflammation via CVF injection (tail vein, i.v.). The control group received PBS injection. The mice (n = 8/each group) were sacrificed 1 h after CVF injection, and the blood, BALF, and lung tissues were collected for index measurement. CMC-Na, carboxymethylcellulose sodium; CVF, cobra venom factor; PBS, phosphate buffered saline; BALF, bronchoalveolar lavage fluid