Fig. 2

ATR ameliorated the CVF-induced acute lung inflammation in mice. The tissue morphology was analyzed 1 h after CVF intravenous administration. The four independent parameters were observed to evaluate the pathological severity response of the lungs: alveolar congestion, hemorrhage, infiltration of leukocytes in the lung tissue, and thickness of the alveolar wall/hyaline membrane formation. a Representative H&E sections of the lung. The original magnifications are × 200 and × 400. b Lung injury score. Results are presented as mean ± SEM (n = 8 in each group). ^#P < 0.05 vs. the control group; _##P < 0.01 vs. the control group; ^**P < 0.01 vs. the CVF group. ATR, atorvastatin; CVF, cobra venom factor; ASA, aspirin; H&E, hematoxylin and eosin